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학술저널
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Alejandro L Suarez (Division of Gastroenterology & Hepatology Medical University of South Carolina Charleston SC US) Qi Pauls (Public Health Sciences Medical University of South Carolina Charleston SC USA) Valerie Durkalski-Mauldin (Public Health Sciences Medical University of South Carolina Charleston SC USA) Peter B Cotton (Division of Gastroenterology & Hepatology Medical University of South Carolina Charleston SC US)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.22 No.3
발행연도
2016.1
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477 - 482 (6page)

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Background/AimsThe reproducibility of sphincter of Oddi manometry (SOM) measurements and results of SOM after sphincterotomy has not beenstudied sufficiently. The aim of our study is to evaluate the reproducibility of SOM and completeness of sphincter ablation. MethodsThe recently published Evaluating Predictors and Interventions in sphincter of Oddi dysfunction (EPISOD) study included 214 subjectswith post-cholecystectomy pain, and fit the criteria of sphincter of Oddi dysfunction type III. They were randomized into 3 arms,irrespective of manometric findings: sham (no sphincterotomy), biliary sphincterotomy, and dual (biliary and pancreatic). Thirtyeightsubjects had both biliary and pancreatic manometries performed twice, at baseline and at repeat endoscopic retrogradecholangiopancreatography after 1-11 months. Sham arm was examined to assess the reproducibility of manometry, and the treatmentarms to assess whether the sphincterotomies were complete (elevated pressures were normalized). ResultsBiliary and pancreatic measurements were reproduced in 7/14 (50%) untreated subjects. All 12 patients with initially elevated biliarypressures in biliary and dual sphincterotomy groups normalized after biliary sphincterotomy. However, 2 of 8 subjects with elevatedpancreatic pressures in the dual sphincterotomy group remained abnormal after pancreatic sphincterotomy. Paradoxically, normalbiliary pressures became abnormal in 1 of 15 subjects after biliary sphincterotomy, and normal pancreatic pressures became abnormalin 5 of 15 patients after biliary sphincterotomy, and in 1 of 9 after pancreatic sphincterotomy. ConclusionsOur data suggest that SOM measurements are poorly reproducible, and question whether we could adequately perform pancreaticsphincterotomy.

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