지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.18 No.4
- 발행연도
- 2018.1
- 수록면
- 264 - 270 (7page)
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초록· 키워드
오류제보하기
Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor derived from Cajal cells originating from the myotonic plexus. The expression of tyrosine kinase (KIT) membrane receptors that are active on KIT is inhibited by the KIT inhibitor imatinib mesylate. GISTs are resistant to conventional chemotherapy, and radiation therapy is not significantly beneficial for GISTs. With the development of imatinib mesylate, approximately 81.6% of patients with advanced and metastatic GIST exhibit an effect above the stabilization response, thereby increasing the survival time. However, imatinib mesylate alone is unlikely to cure metastatic GISTs. Even with a partial or stable response, imatinib mesylate may be used for a longer time period. However, resection of grossly visible lesions should be considered for patients with a stable response during surgical treatment. In this study, we present a case of GIST with liver metastasis after imatinib mesylate treatment, which was followed up without recurrence after partial resection. (Korean J Helicobacter Up Gastrointest Res 2018;18:264-270)
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Miettinen M / 1999 / Gastrointestinal stromal tumors: recent advances in understanding of their biology / Hum Pathol 30:1213~1220
Rubin BP / 2001 / KIT activation is a ubiquitous feature of gastrointestinal stromal tumors / Cancer Res 61:8118~8121
DeMatteo RP / 2000 / Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival / Ann Surg 231:51~58
Molinas Mandel N / 2016 / Clinical and pathological characteristics and their effect on survival in elderly patients with gastrointestinal stromal tumors / J BUON 21:360~365
Demetri GD / 2002 / Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors / N Engl J Med 347:472~480
Rubin BP / 2001 / KIT activation is a ubiquitous feature of gastrointestinal stromal tumors / Cancer Res 61:8118~8121
DeMatteo RP / 2000 / Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival / Ann Surg 231:51~58
Molinas Mandel N / 2016 / Clinical and pathological characteristics and their effect on survival in elderly patients with gastrointestinal stromal tumors / J BUON 21:360~365
Demetri GD / 2002 / Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors / N Engl J Med 347:472~480
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