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논문 기본 정보

자료유형
학술저널
저자정보
김태원 (가톨릭대학교 의과대학 신경과학교실) 한시령 (가톨릭대학교)
저널정보
대한신경집중치료학회 Journal of Neurocritical Care Journal of Neurocritical Care Vol.9 No.2
발행연도
2016.1
수록면
139 - 143 (5page)

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Background: Virchow’s triad, consisting of atrial tissue damage, a hypercoagulable state, and blood stasis, has been used to explain the thrombogenic mechanisms of non-valvular atrial fibrillation (NVAF). Blood stasis is thought to be attributable to loss of left atrial systole and left atrial enlargement, while the hypercoagulable state is partly reflected by elevated serum D-dimer levels. The aim of this study was to evaluate the correlation between risk factors for CHA2DS2-VASc and left atrial enlargement/serum D-dimer levels in order to explore whether LAE with D-dimer elevation is one of the key factors in the thrombogenic mechanisms of atrial fibrillation. Methods: Consecutive patients with acute ischemic stroke due to NVAF who were anticoagulation-naïve were enrolled. All patients were evaluated for left atrial volume index (LAVI) by transthoracic echocardiography. The association between CHA2DS2-VASc scores and LAVI/D-dimer levels was evaluated. Results: A total of 98 anticoagulation-naïve patients who presented with acute ischemic stroke due to NVAF were enrolled in this study. CHA2DS2-VASc scores were significantly correlated with left atrial volume index (r=0.325, P=0.002). There was also a significant correlation between CHA2DS2-VASc scores and serum D-dimer levels (r=0.309, P=0.006). Conclusions: CHA2DS2-VASc scores were associated with left atrial enlargement (LAE) and increased D-dimer levels in anticoagulation-naïve patients with acute ischemic stroke due to NVAF. LAE may play a crucial role in the link between CHA2DS2-VASc risk factors and the development of ischemic stroke, and these hypercoagulable conditions seem to be reflected by an elevation in D-dimer levels.

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