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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,902 - 1,910 (9page)
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Lumbar disc herniation is commonly encountered in clinical practice and can induce sciatica due to mechanical and/or chemical irritation and the release of proinflammatory cytokines. However, symptoms are not confined to the affected spinal cord segment. The purpose of this study was to determine whether multisegmental molecular changes exist between adjacent lumbar spinal segments using a rat model of lumbar disc herniation. Twenty-nine male Sprague-Dawley rats were randomly assigned to either a sham-operated group (n = 10) or a nucleus pulposus (NP)-exposed group (n = 19). Rats in the NP-exposed group were further subdivided into a significant pain subgroup (n = 12) and a no significant pain subgroup (n = 7) using mechanical pain thresholds determined von Frey filaments. Immunohistochemical stainings of microglia (ionized calcium-binding adapter molecule 1; Iba1), astrocytes (glial fibrillary acidic protein; GFAP), calcitonin gene-related peptide (CGRP), and transient receptor potential vanilloid 1 (TRPV1) was performed in spinal dorsal horns and dorsal root ganglions (DRGs) at 10 days after surgery. It was found immunoreactivity for Iba1-positive microglia was higher in the L5 (P = 0.004) dorsal horn and in the ipsilateral L4 (P = 0.009), L6 (P = 0.002), and S1 (P = 0.002) dorsal horns in the NP-exposed group than in the sham-operated group. The expression of CGRP was also significantly higher in ipsilateral L3, L4, L6, and S1 segments and in L5 DRGs at 10 days after surgery in the NP-exposed group than in the sham-operated group (P < 0.001). Our results indicate that lumbar disc herniation upregulates microglial activity and CGRP expression in many adjacent and ipsilateral lumbar spinal segments.
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참고문헌 (40)
참고문헌 신청
Olmarker K / 1997 / The effects of normal, frozen, and hyaluronidase-digested nucleus pulposus on nerve root structure and function / Spine (Phila Pa 1976) 22:471~475
Olmarker K / 1998 / Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury / Spine(Phila Pa 1976) 23:2538~2544
Olmarker K / 1993 / Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots / Spine(Phila Pa 1976) 18:1425~1432
Igarashi T / 2000 / 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats / Spine (Phila Pa 1976) 25:2975~2980
Kallakuri S / 2005 / The effects of epidural application of allografted nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge / Eur Spine J 14:956~964
Olmarker K / 1998 / Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury / Spine(Phila Pa 1976) 23:2538~2544
Olmarker K / 1993 / Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots / Spine(Phila Pa 1976) 18:1425~1432
Igarashi T / 2000 / 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats / Spine (Phila Pa 1976) 25:2975~2980
Kallakuri S / 2005 / The effects of epidural application of allografted nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge / Eur Spine J 14:956~964
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