Analysis of risk factors associated with survival in human epidermal growth factor receptor 2-positive ductal carcinoma in situ using Korean Breast Cancer Society Database

Sol Ji Ahn; Chang Ik Yoon; Pill Sun Paik; Tae-Kyung Yoo; Namsun Park; Eun Sook Lee; Jung Eun Choi; Joon Jeong; Hyun Jo Youn; Woo-Chan Park

추천

검색

질문

자료유형: 학술저널

저자정보: Sol Ji Ahn (Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea) Chang Ik Yoon (Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea) Pill Sun Paik (Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea) Tae-Kyung Yoo (Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea) Namsun Park (Ewha Womans University Cancer Center Hospital for Women) Eun Sook Lee (National Cancer Center) Jung Eun Choi (Yeungnam University College of Medicine) Joon Jeong (Gangnam Severance Hospital, Yonsei University College of Medicine) Hyun Jo Youn (Jeonbuk National University College of Medicine) Woo-Chan Park (Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.101 No.6

발행연도: 2021.12

수록면: 315 - 321 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: This study was performed to identify the risk of mortality in patients diagnosed with human epidermal growth factor receptor 2 (HER2)-positive ductal carcinoma in situ (DCIS).
Methods: We selected 2,592 patients with HER2-positive DCIS from Korean Breast Cancer Society (KBCS) database between January 1997 and December 2019. Patients who received neoadjuvant chemotherapy were excluded. Logistic regression analysis was used to determine the association between clinical factors and overall death after adjusting for tumor and clinical characteristics. Mortality data were modified using the Statistics Korea data.
Results: Thirty deaths (1.2%) were identified out of 2,592 patients in the KBCS database. In the univariate logistic regression analysis, older age, higher body mass index (BMI), type of breast surgery (mastectomy), estrogen receptor-negative, progesterone receptor-negative, and exposure to endocrine therapy were significant clinical factors associated with death. In the multivariate analysis, age (hazard ratio [HR], 1.062; 95% confidence interval [CI], 1.015–1.111; P = 0.006), BMI (HR, 1.179; 95% CI, 1.032–1.347, P = 0.016), breast surgery type (mastectomy vs. lumpectomy; HR, 0.285; 95% CI, 0.096–0.844; P = 0.024), and endocrine therapy (HR, 0.314; 95% CI, 0.099–0.995; P = 0.049) were significant risk factors for mortality.
Conclusion: Advanced age, higher BMI, mastectomy, and the absence of endocrine therapy were factors associated with poor survival of patients with HER2-positive DCIS. This finding requires further validation combined with additional analysis of large databases.

#Death #Human epidermal growth factor receptor 2 #Mortality #Noninfiltrating intraductal carcinoma

참고문헌 (13)

참고문헌 신청

홍세리 / 2020 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017 / Cancer Research and Treatment 52(2):335~350

Page DL / 1982 / Intraductal carcinoma of the breast: follow-up after biopsy only / Cancer 49:751~758

Bryan BB / 2006 / Ductal carcinoma in situ with basal-like phe-notype: a possible precursor to invasive basal-like breast cancer / Mod Pathol 19:617~621

Allred DC / 2012 / Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ:a study based on NSABP protocol B-24 / J Clin Oncol 30:1268~1273

Hoque A / 2002 / Her-2/neu gene amplification in ductal carcinoma in situ of the breast / ancer Epidemiol Biomarkers Prev 11:587~590

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!