지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.2
- 수록면
- 1 - 13 (13page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Bitter taste receptors are taste signaling pathway mediators, and are also expressed and function in extra-gustatory organs. Skin aging affects the quality of life and may lead to medical issues. The purpose of this study was to better understand the anti-skin aging effects of bitter taste receptors in D-galactose (D-gal)-induced aged human keratinocytes, HaCaT cells.
MATERIALS/METHODS: Expressions of bitter taste receptors in HaCaT cells and mouse skin tissues were examined by polymerase chain reaction assay. Bitter taste receptor was overexpressed in HaCaT cells, and D-gal was treated to induce aging. We examined the effects of bitter taste receptors on aging by using β-galactosidase assay, wound healing assay, and Western blot assay.
RESULTS: TAS2R16 and TAS2R10 were expressed in HaCaT cells and were upregulated by D-gal treatment. TAS2R16 exerted protective effects against skin aging by regulating p53 and p21, antioxidant enzymes, the SIRT1/mechanistic target of rapamycin pathway, cell migration, and epithelial-mesenchymal transition markers. TAS2R10 was further examined to confirm a role of TAS2R16 in cellular senescence and wound healing in D-gal-induced aged HaCaT cells.
CONCLUSIONS: Our results suggest a novel potential preventive role of these receptors on skin aging by regulating cellular senescence and wound healing in human keratinocyte, HaCaT.
MATERIALS/METHODS: Expressions of bitter taste receptors in HaCaT cells and mouse skin tissues were examined by polymerase chain reaction assay. Bitter taste receptor was overexpressed in HaCaT cells, and D-gal was treated to induce aging. We examined the effects of bitter taste receptors on aging by using β-galactosidase assay, wound healing assay, and Western blot assay.
RESULTS: TAS2R16 and TAS2R10 were expressed in HaCaT cells and were upregulated by D-gal treatment. TAS2R16 exerted protective effects against skin aging by regulating p53 and p21, antioxidant enzymes, the SIRT1/mechanistic target of rapamycin pathway, cell migration, and epithelial-mesenchymal transition markers. TAS2R10 was further examined to confirm a role of TAS2R16 in cellular senescence and wound healing in D-gal-induced aged HaCaT cells.
CONCLUSIONS: Our results suggest a novel potential preventive role of these receptors on skin aging by regulating cellular senescence and wound healing in human keratinocyte, HaCaT.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Bitter taste receptors protect against skin aging by inhibiting cellular senescence and enhancing wound healing
Nutrition Research and Practice
2022 .02
-
Bioelectronic tongue for sensing bitter tastes based on human bitter taste receptor proteins
한국진공학회 학술발표회초록집
2021 .02
-
Molecular sensors in the taste system of Drosophila
Genes & Genomics
2023 .06
-
Expression of TAS2R14 in the Intestinal Endocrine Cells of Non-Human Primates
Genes & Genomics
2021 .01
-
Advances in Optical Tools to Study Taste Sensation
Molecules and Cells
2022 .12
-
Umami taste receptor suppresses cancer cachexia by regulating skeletal muscle atrophy in vivo and in vitro
Nutrition Research and Practice
2024 .08
-
Umami taste receptor suppresses cancer cachexia by regulating skeletal muscle atrophy in vivo and in vitro
Nutrition Research and Practice
2024 .08
-
Bitter Taste Receptor TAS2R38 Genetic Variation (rs10246939), Dietary Nutrient Intake, and Bio-Clinical Parameters in Koreans
Clinical Nutrition Research
2023 .01
-
Lipoteichoic Acid Isolated from Staphylococcus aureus Induces Both Epithelial-Mesenchymal Transition and Wound Healing in HaCaT Cells
Journal of Microbiology and Biotechnology
2017 .01
-
충청지역 일부 노인의 연령에 따른 맛 선호도, 식행동 및 식습관 비교
동아시아식생활학회지
2019 .04
-
Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers
Genes & Genomics
2022 .11
-
Microtubule function and dysfunction in the nervous system
Molecules and Cells
2024 .01
-
Topological physics in antiferromagnetic van der Waals Co1/3-TaS₂
한국자기학회 학술연구발표회 논문개요집
2024 .05
-
Association between taste perception, nutrient intake, and mental health in young Japanese women
Nutrition Research and Practice
2019 .02
-
Association between taste perception, nutrient intake, and mental health in young Japanese women
Nutrition Research and Practice
2019 .02
-
In Vitro and in Vivo Wound Healing Properties of Plasma and Serum from Crocodylus siamensis Blood
Journal of Microbiology and Biotechnology
2016 .01
-
수용모델을 사용한 우리나라 초미세먼지(PM2.5) 오염원 기여도 연구
한국대기환경학회 학술대회논문집
2017 .11
-
Nutrigenomics reveals potential genetic underpinning of diverse taste preference of Chinese men
Genes & Genomics
2021 .01
-
효소처리를 달리한 여주즙의 이화학적 특성 및 쓴맛 저감 효과
한국생활과학회 학술대회논문집
2021 .11
-
Neural circuits for taste sensation
Molecules and Cells
2024 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0