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논문 기본 정보

자료유형
학술저널
저자정보
Gyeong-Mi Kim (Chosun University) Seong-Yong Moon (Chosun University) Jae-Seek You (Chosun University) Gyeong-Yun Kim (Chosun University) Ji-Su Oh (Chosun University)
저널정보
대한안면통증구강내과학회 Journal of Oral Medicine and Pain Journal of Oral Medicine and Pain Vol.47 No.1
발행연도
2022.3
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1 - 9 (9page)

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초록· 키워드

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Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of antiresorptive agents and bone-modifying agents. It is of the utmost importance to know the management of the MRONJ to improve the patient’s quality of life. This study comprehensively reviews the current definitions of MRONJs, and antiresorptive medications, clinical manifestation and staging, risk factors, treatment strategies, and prevention methods of MRONJ. The disease is defined as an exposure of bone and osteonecrosis of the jaw in the oral cavity for at least 8 weeks in patients taking antiresorptive drugs or antiangiogenic agents and with no history of radiotherapy treatment of the jaws. Many articles have reported risk factors associated with MRONJ such as systemic diseases, antiresorptive medication, oral infection, and poor oral hygiene. Osteonecrosis and antiresorptive medications including bisphosphonate and denosumab have been strongly associated, but the pathology of MRONJ is only limited. Hence, an effective and appropriate management and treatment for MRONJ is still to be defined. The objectives of MRONJ treatment are to minimize osteonecrosis and relieve symptoms, and many treatments are suggested from conservative treatment to marginal resection, but this remains controversial. Appropriate treatment of MRONJ remained difficult, although many studies are being covered.

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INTRODUCTION
ANTIRESORPTIVE MEDICATIONS
CLINICAL MANIFESTATION AND STAGING
RISK FACTOR
TREATMENT STRATEGIES FOR MEDICATIONRELATEDOSTEONECROSIS OF THE JAWS
PREVENTION METHOD OF MEDICATIONRELATEDOSTEONECROSIS OF THE JAWS
CONCLUSION
REFERENCES

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