지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.5
- 수록면
- 387 - 395 (9page)
이용수
초록· 키워드
오류제보하기
Background: Fermentation may alter the bioavailability of certain compounds, which may affect their efficacy and pharmacological responses. This study investigated the antiplatelet effects of red ginseng extract (RGE) and fermented red ginseng extract (FRG).
Methods: A rodent model was used to evaluate the antiplatelet and antithrombotic effects of the extracts. Rats were orally fed with human equivalent doses of the extracts for 1 week and examined for various signaling pathways using standard in vivo and ex vivo techniques. Light transmission aggregometry was performed, and calcium mobilization, dense granule secretion, integrin α<SUB>IIb</SUB>β₃-mediated signaling molecules, cyclic nucleotide signaling events, and various protein molecules were evaluated ex vivo in collagen-stimulated washed platelets. Furthermore, antithrombotic properties were evaluated using a standard acute pulmonary thromboembolism model, and the effects on hemostasis were investigated using rat and mice models.
Results: Both RGE and FRG significantly inhibited platelet aggregation, calcium mobilization, and dense granule secretion along with integrin-mediated fibrinogen binding and fibrinogen adhesion. cAMP levels were found to be elevated in RGE-treated rat platelets. Ginseng extracts did not exert any effect on prothrombin time and activated partial thromboplastin time. RGE-treated mice showed significantly better survival under thrombosis than FRG-treated mice, with no effects on hemostasis, whereas FRGtreated mice exhibited a slight increment in bleeding time.
Conclusion: Both extracts, especially RGE, are remarkable supplements to maintain cardiovascular health and are potential candidates for the treatment and prevention of platelet-related cardiovascular disorders.
Methods: A rodent model was used to evaluate the antiplatelet and antithrombotic effects of the extracts. Rats were orally fed with human equivalent doses of the extracts for 1 week and examined for various signaling pathways using standard in vivo and ex vivo techniques. Light transmission aggregometry was performed, and calcium mobilization, dense granule secretion, integrin α<SUB>IIb</SUB>β₃-mediated signaling molecules, cyclic nucleotide signaling events, and various protein molecules were evaluated ex vivo in collagen-stimulated washed platelets. Furthermore, antithrombotic properties were evaluated using a standard acute pulmonary thromboembolism model, and the effects on hemostasis were investigated using rat and mice models.
Results: Both RGE and FRG significantly inhibited platelet aggregation, calcium mobilization, and dense granule secretion along with integrin-mediated fibrinogen binding and fibrinogen adhesion. cAMP levels were found to be elevated in RGE-treated rat platelets. Ginseng extracts did not exert any effect on prothrombin time and activated partial thromboplastin time. RGE-treated mice showed significantly better survival under thrombosis than FRG-treated mice, with no effects on hemostasis, whereas FRGtreated mice exhibited a slight increment in bleeding time.
Conclusion: Both extracts, especially RGE, are remarkable supplements to maintain cardiovascular health and are potential candidates for the treatment and prevention of platelet-related cardiovascular disorders.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Red ginseng extract inhibits lipopolysaccharide-induced platelet-leukocyte aggregates in mice
Journal of Ginseng Research
2024 .07
-
Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation
Journal of Ginseng Research
2017 .10
-
A comparative study on immune-stimulatory and antioxidant activities of various types of ginseng extracts in murine and rodent models
Journal of Ginseng Research
2018 .10
-
Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
Journal of Ginseng Research
2015 .04
-
Antiplatelet Effects of Garlic and Chitosan : a Comparative Study between Fermented and Non-Fermented Preparations
대한의생명과학회지
2018 .09
-
Effect of Korean Red Ginseng extract on colorectal lung metastasis through inhibiting the epitheliale-mesenchymal transition via transforming growth factor-β1/Smad-signaling-mediated Snail/E-cadherin expression
Journal of Ginseng Research
2019 .01
-
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production
Journal of Ginseng Research
2022 .01
-
COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway
Journal of Ginseng Research
2022 .03
-
The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation
Journal of Ginseng Research
2017 .01
-
Korean Red Ginseng and Portulaca oleracea Extracts Attenuate Lipopolysaccharide-induced Inflammation via Downregulation of Nuclear Factor Kappa-B and the Mitogen-activated Protein Kinase Signaling Pathway in Macrophage Cell Line RAW 264.7
대한의생명과학회지
2021 .06
-
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes
Journal of Ginseng Research
2021 .05
-
Protective role of saponin derived from Korean Red Ginseng in keratinocytes
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Fermentation of red ginseng extract by the probiotic Lactobacillus plantarum KCCM 11613P: ginsenoside conversion and antioxidant effects
Journal of Ginseng Research
2019 .01
-
A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng)
Journal of Ginseng Research
2018 .06
-
Improvement of antithrombotic activity of red ginseng extract by nanoencapsulation using chitosan and antithrombotic cross-linkers: polyglutamic acid and fucodian
Journal of Ginseng Research
2021 .03
-
Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro
Journal of Ginseng Research
2017 .04
-
The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo
Journal of Ginseng Research
2023 .09
-
Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium
Journal of Ginseng Research
2023 .05
-
Newly identified maltol derivatives in Korean Red Ginseng and their biological influence as antioxidant and anti-inflammatory agents
Journal of Ginseng Research
2023 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2022-524-001328766