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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 169 - 174 (6page)
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The aim of this study was to investigate the effect and action mechanism of quercetin on penile corpus cavernosum smooth muscle (PCCSM). PCCSM precontracted with phenylephrine (Phe) was treated with four different concentrations of quercetin (10<sup>-7</sup>, 10<sup>-6</sup>, 10<sup>-5</sup> and 10<sup>-4</sup> M). PCCSM were preincubated with N-Nitro-L-arginine methyl ester hydrochloride (L-NAME) and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to block nitric oxide synthase and guanylate cyclase, respectively. The changes in PCCSM tension were recorded, and cyclic nucleotides in the perfusate were measured by radioimmunoassay. The interactions of quercetin with phosphodiesterase type 5 inhibitors (PDE5-Is) such as sildenafil, udenafil and mirodenafil, were also evaluated. PCCSM relaxation induced by quercetin occurred in a concentrationdependent manner. The application of quercetin to PCCSM pre-treated with L-NAME and ODQ significantly inhibited the relaxation. Quercetin significantly increased cGMP in the perfusate. Furthermore, quercetin enhanced PDE5-Is-induced relaxation of PCCSM. Quercetin relaxed the PCCSM by activating the NO-cGMP signaling pathway, and it may be a therapeutic candidate or an alternative treatment for patients with erectile dysfunction who do not completely respond to PDE5-Is.
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참고문헌 (21)
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Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells
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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
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Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin
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Quercetin reduces the injury-induced reduction of γ-enolase expression in a middle cerebral artery occlusion animal model
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Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model and HT-22 cells
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Modulation of the Expression of the GABAA Receptor β1 and β3 Subunits by Pretreatment with Quercetin in the KA Model of Epilepsy in Mice
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Effect of proton beam irradiation on cytotoxicity and anti-inflammatory activity of quercetin
한국실험동물학회 학술발표대회 논문집
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Comparative Effects of Dietary Quercetin and Rutin in Rats Fed with the Lieber-DeCarli Ethanol Diet
Natural Product Sciences
2017 .09
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Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner
The Korean Journal of Physiology & Pharmacology
2019 .01
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Antitumor and apoptotic effect of quercetin in human melanoma cells involving JNK/P38 MAPK signaling activation
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Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice
Obstetrics & Gynecology Science
2019 .01
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Direct vascular actions of quercetin in aorta from renal hypertensive rats
Kidney Research and Clinical Practice
2016 .01
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Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils -
Journal of Pharmacopuncture
2017 .06
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