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학술저널
저자정보
이진우 (Dongguk University Ilsan Hospital) Jung Jiyun (Dongguk University Ilsan Hospital Ilsan Republic of Korea) 이장욱 (동국대학교) Park Jung Tak (Department of Internal Medicine and Institute of Kidney Disease Research Yonsei University College) Jung Chan-young (Dongguk University) Kim Yong Chul (Seoul National University College of Medicine) Kim Dong Ki (Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Kor) 이정표 (서울대학교) 신성준 (Dongguk University Ilsan Hospital) 박재윤 (동국대학교)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.41 No.3
발행연도
2022.6
수록면
332 - 341 (10page)
DOI
10.23876/j.krcp.21.110

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Background: Comorbid conditions impact the survival of patients with severe acute kidney injury (AKI) who require continuous renal replacement therapy (CRRT). The weights assigned to comorbidities in predicting survival vary based on type of index, disease, and advances in management of comorbidities. We developed a modified Charlson Comorbidity Index (CCI) for use in patients with AKI requiring CRRT (mCCI-CRRT) and improved the accuracy of risk stratification for mortality. Methods: A total of 828 patients who received CRRT between 2008 and 2013, from three university hospital cohorts was included to develop the comorbidity score. The weights of the comorbidities were recalibrated using a Cox proportional hazards model adjusted for demographic and clinical information. The modified index was validated in a university hospital cohort (n = 919) using the data of patients treated from 2009 to 2015. Results: Weights for dementia, peptic ulcer disease, any tumor, and metastatic solid tumor were used to recalibrate the mCCI-CRRT. Use of these calibrated weights achieved a 35.4% (95% confidence interval [CI], 22.1%?48.1%) higher performance than unadjusted CCI in reclassification based on continuous net reclassification improvement in logistic regression adjusted for age and sex. After additionally adjusting for hemoglobin and albumin, consistent results were found in risk reclassification, which improved by 35.9% (95% CI, 23.3%?48.5%). Conclusion: The mCCI-CRRT stratifies risk of mortality in AKI patients who require CRRT more accurately than does the original CCI, suggesting that it could serve as a preferred index for use in clinical practice.

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