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논문 기본 정보

자료유형
학술저널
저자정보
Jihyun An (Department of Gastroenterology and Hepatology Hanyang University College of Medicine Seoul) Hyung-Don Kim (Department of Oncology Asan Medical Center University of Ulsan College of Medicine) Seon-Ok Kim (Department of Biostatistics and Clinical Epidemiology Asan Medical Center) Ha Il Kim (Department of Gastroenterology Kyung Hee University Hospital at Gangdong) Gi Won Song (Department of Surgery Asan Medical Center University of Ulsan College of Medicine) Han Chu Lee (Asan Liver Center Asan Medical Center University of Ulsan College of Medicine) Ju Hyun Shim (Asan Liver Center Asan Medical Center University of Ulsan College of Medicine)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제28권 제1호
발행연도
2022.1
수록면
67 - 76 (10page)
DOI
10.3350/cmh.2021.0202

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초록· 키워드

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Background/Aims: We aimed to investigate the silent atherosclerotic burden of cervicocephalic vessels in cirrhotic patients compared with the general population, as well as the relevant risk factors including coronary parameters. Methods: This study included 993 stroke-free patients with liver cirrhosis (LC) who underwent magnetic resonance angiography (MRA) of the head and neck as a pre-liver transplant assessment and 6,099 health checkup participants who underwent MRA examination. The two cohorts were matched for cerebrovascular risk factors, and the prevalence of atherosclerosis in major intracranial and extracranial arteries was compared in 755 matched pairs. Moreover, traditional, hepatic, and coronary variables related to cerebral atherosclerosis were assessed in cirrhotic patients. Results: Overall, intracranial atherosclerosis was significantly less prevalent in the LC group than in the matched control group (2.3% vs. 5.4%, P=0.002), whereas the prevalence of extracranial atherosclerosis was similar (4.4% vs. 5.8%, P=0.242). These results were maintained in multivariate analyses of the pooled samples, with corresponding adjusted odds ratios [ORs] of LC of 0.56 and 0.77 (95% confidence intervals [CIs], 0.36?0.88 and 0.55?1.09). In the LC group, lower platelet count was inversely correlated with intracranial atherosclerosis (adjusted OR, 0.31; 95% CI, 0.13?0.76). Coronary artery calcium (CAC) score ≥100 was the only predictive factor for both intracranial and extracranial atherosclerosis (adjusted ORs, 4.06 and 5.43, respectively). Conclusions: LC confers protection against intracranial atherosclerosis, and thrombocytopenia may be involved in this protective effect. High CAC score could serve as a potential surrogate for cervicocerebral vascular screening in asymptomatic cirrhotic patients.

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