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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 883 - 892 (10page)
- DOI
- 10.14348/molcells.2021.0014
이용수
초록· 키워드
오류제보하기
Genome-wide chromosome conformation capture (3C)- based high-throughput sequencing (Hi-C) has enabled identification of genome-wide chromatin loops. Because the Hi-C map with restriction fragment resolution is intrinsically associated with sparsity and stochastic noise, Hi-C data are usually binned at particular intervals; however, the binning method has limited reliability, especially at high resolution. Here, we describe a new method called HiCORE, which provides simple pipelines and algorithms to overcome the limitations of single-layered binning and predict core chromatin regions with three-dimensional physical interactions. In this approach, multiple layers of binning with slightly shifted genome coverage are generated, and interacting bins at each layer are integrated to infer narrower regions of chromatin interactions. HiCORE predicts chromatin looping regions with higher resolution, both in human and Arabidopsis genomes, and contributes to the identification of the precise positions of potential genomic elements in an unbiased manner.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Cameron, C. J. F. / 2020 / HIFI : estimating DNA-DNA interaction frequency from Hi-C data at restriction-fragment resolution / Genome Biol 21:11
Cao, Y. / 2020 / Accurate loop calling for 3D genomic data with cLoops / Bioinformatics 36:666~675
최원영 / 2020 / NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells / Molecules and Cells 43(12):1011~1022
Crevillén, P. / 2013 / A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization / EMBO J 32:140~148
Dekker, J. / 2002 / Capturing chromosome conformation / Science 295:1306~1311
Cao, Y. / 2020 / Accurate loop calling for 3D genomic data with cLoops / Bioinformatics 36:666~675
최원영 / 2020 / NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells / Molecules and Cells 43(12):1011~1022
Crevillén, P. / 2013 / A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization / EMBO J 32:140~148
Dekker, J. / 2002 / Capturing chromosome conformation / Science 295:1306~1311
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