Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats

Wang Yueping; Yao Weifan; Li Bo; Qian Shiyun; Wei Binbin; Gong Shiqiang; Wang Jing; Liu Mingyan; Wei Minjie

doi:10.1038/s12276-020-00534-2

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자료유형: 학술저널

저자정보: Wang Yueping (China Medical University) Yao Weifan (China Medical University) Li Bo (China Medical University) Qian Shiyun (China Medical University) Wei Binbin (China Medical University) Gong Shiqiang (China Medical University) Wang Jing (China Medical University) Liu Mingyan (China Medical University) Wei Minjie (China Medical University)

저널정보: 대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제52권

발행연도: 2020.12

수록면: 1 - 17 (17page)

DOI: 10.1038/s12276-020-00534-2

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Gut microbiota dysbiosis has a significant role in the pathogenesis of metabolic diseases, including obesity. Nuciferine (NUC) is a main bioactive component in the lotus leaf that has been used as food in China since ancient times. Here, we examined whether the anti-obesity effects of NUC are related to modulations in the gut microbiota. Using an obese rat model fed a HFD for 8 weeks, we show that NUC supplementation of HFD rats prevents weight gain, reduces fat accumulation, and ameliorates lipid metabolic disorders. Furthermore, 16S rRNA gene sequencing of the fecal microbiota suggested that NUC changed the diversity and composition of the gut microbiota in HFD-fed rats. In particular, NUC decreased the ratio of the phyla Firmicutes/Bacteroidetes, the relative abundance of the LPS-producing genus Desulfovibrio and bacteria involved in lipid metabolism, whereas it increased the relative abundance of SCFA-producing bacteria in HFD-fed rats. Predicted functional analysis of microbial communities showed that NUC modified genes involved in LPS biosynthesis and lipid metabolism. In addition, serum metabolomics analysis revealed that NUC effectively improved HFD-induced disorders of endogenous metabolism, especially lipid metabolism. Notably, NUC promoted SCFA production and enhanced intestinal integrity, leading to lower blood endotoxemia to reduce inflammation in HFD-fed rats. Together, the anti-obesity effects of NUC may be related to modulations in the composition and potential function of gut microbiota, improvement in intestinal barrier integrity and prevention of chronic low-grade inflammation. This research may provide support for the application of NUC in the prevention and treatment of obesity.

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