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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제1호
- 발행연도
- 2018.1
- 수록면
- 19 - 41 (23page)
- DOI
- 10.1007/s40005-017-0361-5
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초록· 키워드
오류제보하기
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas in pharmaceutics.
Research has shown that ASDs offer unique advantages in improving the bioavailability of poorly watersoluble drugs over conventional delivery systems. The various formulations and manufacturing processes of ASDs affect their physicochemical stability, processability, and drug release characteristics. Therefore, the characterization of ASDs is critical in all stages of product development, including preformulation screening, formulation development, process scale-up, and commercial manufacturing.
Proper characterization allows for the rational selection of formulation composition and manufacturing processing methods and allows for high-quality drug products. In this review, we present the most commonly used methods for characterizing the solid-state properties of ASDs, and we discuss their mechanisms, applications, advantages, and disadvantages.
We also provide a brief overview of the methods used to characterize ASDs behavior in aqueous media.
These methods are divided into three different categories: microscopic and surface analysis methods, thermal analysis methods, and spectroscopic methods. In addition, this article discusses a number of emerging techniques. Last, we discuss how these methods are applied at different stages in the ASDs product development life cycle.
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참고문헌 (152)
참고문헌 신청
Alhijjaj M / 2015 / Thermal analysis by structural characterization as a method for assessing heterogeneity in complex solid pharmaceutical dosage forms / Anal Chem 87(21):10848~10855
Alhijjaj M / 2017 / Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography / Pharm Res 34(5):971~989
Almeida A / 2012 / Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations / Int J Pharm 439(1):223~229
Alonzo DE / 2010 / Understanding the behavior of amorphous pharmaceutical systems during dissolution / Pharm Res 27(4):608~618
Alvarez-Murga M / 2012 / Diffraction/scattering computed tomography for three-dimensional characterization of multi-phase crystalline and amorphous materials / J Appl Crystallogr 45(6):1109~1124
Alhijjaj M / 2017 / Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography / Pharm Res 34(5):971~989
Almeida A / 2012 / Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations / Int J Pharm 439(1):223~229
Alonzo DE / 2010 / Understanding the behavior of amorphous pharmaceutical systems during dissolution / Pharm Res 27(4):608~618
Alvarez-Murga M / 2012 / Diffraction/scattering computed tomography for three-dimensional characterization of multi-phase crystalline and amorphous materials / J Appl Crystallogr 45(6):1109~1124
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