지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제2호
- 발행연도
- 2017.3
- 수록면
- 197 - 204 (8page)
이용수
초록· 키워드
오류제보하기
In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as the production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effect of oleanolic acid. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-1β (IL-1β)-induced gene expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), ADAMTS-5 and type II collagen. In rabbit articular chondrocytes, the effects of oleanolic acid on IL-1β-induced secretion and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively. The effect of oleanolic acid on in vivo MMP-3 protein production was also examined, after intra-articular injection to the knee joint of rat. The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo. These results suggest that oleanolic acid can regulate the activity, secretion and gene expression of MMP-3, by directly acting on articular chondrocytes.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Aigner T / 2002 / Molecular pathology and pathobiology of osteoarthritic cartilage / Cell Mol Life Sci 59:5~18
Mankin HJ / 1982 / The response of articular cartilage to mechanical injury / J Bone Joint Surg Am 64:460~466
Dean DD / 1989 / Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage / J Clin Invest 84:678~685
Kullich W / 2007 / Effect of the NSAID nimesulide on the radical scavenger glutathione S-transferase in patients with osteoarthritis of the knee / Curr Med Res Opin 23:1981~1986
Birkedal-Hansen H / 1993 / Matrix metalloproteinases : a review / Crit Rev Oral Biol Med 4:197~250
Mankin HJ / 1982 / The response of articular cartilage to mechanical injury / J Bone Joint Surg Am 64:460~466
Dean DD / 1989 / Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage / J Clin Invest 84:678~685
Kullich W / 2007 / Effect of the NSAID nimesulide on the radical scavenger glutathione S-transferase in patients with osteoarthritis of the knee / Curr Med Res Opin 23:1981~1986
Birkedal-Hansen H / 1993 / Matrix metalloproteinases : a review / Crit Rev Oral Biol Med 4:197~250
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Betulin suppressed interleukin-1b-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat
The Korean Journal of Physiology & Pharmacology
2017 .01
-
Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Oleanolic acid 3-acetate, a minor element of ginsenosides, induces apoptotic cell death in ovarian carcinoma and endometrial carcinoma cells via the involvement of a reactive oxygen species-independent mitochondrial pathway
Journal of Ginseng Research
2020 .01
-
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion
Restorative Dentistry and Endodontics
2020 .01
-
Pleiotropic Roles of Metalloproteinases in Hematological Malignancies: an Update
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions
Clinical and Experimental Otorhinolaryngology
2015 .01
-
The therapeutic effect of oleanolic acid acetate on experimental autoimmune encephalomyelitis
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
대한구강악안면외과학회지
2018 .01
-
MMP2 Gene-735 C/T and MMP9 gene -1562 C/T Polymorphisms in JAK2V617F Positive Myeloproliferative Disorders
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Secretion and Expression of Matrix Metalloproteinase-2 and 9 from Bone Marrow Mononuclear Cells in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
An Overview of Matrix Metalloproteinase 9 Polymorphism and Gastric Cancer Risk
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Evaluation of Serum Matrix Metalloproteinase-3 as an Objective Indicator for the Disease Activity in Rheumatoid Arthritis Patients Treated With Methotrexate Versus Tocilizumab: 24-week Results From a Prospective Randomized Controlled Study
대한류마티스학회지
2022 .04
-
Effect of Prostaglandin E2 Agonist Omidenepag on the Expression of Matrix Metalloproteinase in Trabecular Meshwork Cells
Korean Journal of Ophthalmology
2022 .04
-
Matrix Metalloproteinase-9 -1562T Allele and its Combination with MMP-2 -735 C Allele are Risk Factors for Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Anti-osteoarthritis effects of Pomegranate, Eucommiae cortex and Achyranthis radix extracts on the primary cultured rat articular chondrocytes
대한예방한의학회지
2017 .01
-
MicroRNA-29 Family Suppresses the Invasion of HT1080 Human Fibrosarcoma Cells by Regulating Matrix Metalloproteinase 2 Expression
전남의대학술지
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0