지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제3호
- 발행연도
- 2017.5
- 수록면
- 279 - 286 (8page)
이용수
초록· 키워드
오류제보하기
The root bark extract of Aralia taibaiensis is used traditionally for the treatment of diabetes mellitus in China. The total saponin extracted from Aralia Taibaiensis (sAT) has effective combined antihyperglycemic and hypolipidemic activities in experimental type 2 diabetic rats. However, the active compounds have not yet been fully investigated. In the present study, we examined effects of twelve triterpenoid saponins on AMP-activated protein kinase (AMPK) activation, and found that compound 28-O-β-D-glucopyranosyl ester (AT12) significantly increased phosphorylation of AMPK and Acetyl-CoA carboxylase (ACC). AT12 effectively decreased blood glucose, triglyceride (TG), free fatty acid (FFA) and low density lipoprotein-cholesterol (LDL-C) levels in the rat model of type 2 diabetes mellitus (T2DM). The mechanism by which AT12 activated AMPK was subsequently investigated. Intracellular ATP level and oxygen consumption were significantly reduced by AT12 treatment. The findings suggested AT12 was a novel AMPK activator, and could be useful for the treatment of metabolic diseases.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Zhang BB / 2009 / AMPK : an emerging drug target for diabetes and the metabolic syndrome / Cell Metab 9:407~416
Adachi Y / 2014 / Petasin activates AMP-activated protein kinase and modulates glucose metabolism / J Nat Prod 77:1262~1269
Baur JA / 2006 / Resveratrol improves health and survival of mice on a high-calorie diet / Nature 444:337~342
Xi M / 2010 / Antioxidant and antiglycation properties of triterpenoid saponins from Aralia taibaiensis traditionally used for treating diabetes mellitus / Redox Rep 15:20~28
Weng Y / 2014 / Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats / J Ethnopharmacol 152:553~560
Adachi Y / 2014 / Petasin activates AMP-activated protein kinase and modulates glucose metabolism / J Nat Prod 77:1262~1269
Baur JA / 2006 / Resveratrol improves health and survival of mice on a high-calorie diet / Nature 444:337~342
Xi M / 2010 / Antioxidant and antiglycation properties of triterpenoid saponins from Aralia taibaiensis traditionally used for treating diabetes mellitus / Redox Rep 15:20~28
Weng Y / 2014 / Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats / J Ethnopharmacol 152:553~560
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema
Tuberculosis and Respiratory Diseases
2015 .01
-
Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?
International Neurourology Journal
2015 .01
-
Impairment of AMPK-α2 augments detrusor contractions in bladder ischemia
Investigative and Clinical Urology
2021 .09
-
Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator
Endocrinology and Metabolism
2024 .02
-
Reserpine treatment activates AMP activated protein kinase (AMPK)
Natural Product Sciences
2017 .09
-
Anti-adipogenic effect of the flavonoids through the activation of AMPK in palmitate (PA)-treated HepG2 cells
Journal of Veterinary Science
2022 .01
-
Resveratrol attenuates lipopolysaccharide-induced dysfunction of blood-brain barrier in endothelial cells via AMPK activation
The Korean Journal of Physiology & Pharmacology
2016 .07
-
Effects of Compounds from Physalis angulata on Fatty Acid Synthesis and Glucose Metabolism in HepG2 Cells via the AMP-activated Protein Kinase Pathway
Natural Product Sciences
2020 .09
-
Atomoxetine and Fluoxetine Activate AMPK-ACC-CPT1 Pathway in Human SH-SY5Y and U-87 MG Cells
PSYCHIATRY INVESTIGATION
2023 .04
-
An optimized herbal medicine HTB attenuates hyperlipidemia by activating the AMPK/SREBP2/PCSK9 signaling pathway
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Regulation of exercise-stimulated glucose uptake in skeletal muscle
Annals of Pediatirc Endocrinology & Metabolism
2016 .01
-
The beneficial effect of Coix lacryma-jobi var. ma-yuen (Roman.) Stapf sprout the activation of LKB1/AMPK/SIRT1 signaling pathway on obesity
한국실험동물학회 학술발표대회 논문집
2021 .07
-
17Beta-estradiol Stimulates Glucose Uptake Through Estrogen Receptor and AMP-activated Protein Kinase Activation in C2C12 Myotubes
Journal of Obesity & Metabolic Syndrome
2016 .01
-
The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells
Journal of Veterinary Science
2021 .11
-
Artemisia annua extract ameliorates high-fat diet-induced fatty liver by activating AMPK
Journal of Biomedical and Translational Research
2020 .01
-
Humanin suppresses receptor activator of nuclear factor-B ligand-induced osteoclast differentiation via AMP-activated protein kinase activation
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Anti-diabetic activities of catalpol in db/db mice
The Korean Journal of Physiology & Pharmacology
2016 .03
-
무막줄기세포추출물의 3T3-L1 세포에서 포도당 흡수 촉진 효과
한방비만학회지
2019 .01
-
[독성병리] Anticancer effect of [6]-gingerol via activation of AMPK and suppression of AKT/mTOR signaling pathway in oral cancer cell
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8+ T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection
Immune Network
2019 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0