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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.9
- 수록면
- 509 - 518 (10page)
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초록· 키워드
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Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape, local invasion, and metastasis of GBM. Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells. However, we found strikingly different patterns of expression of cytokines and chemokines between H2O2-treated CRT-MG cells cultured in low- and high-glucose medium. These results suggest that astroglioma and microglia cells exhibit distinct patterns of cytokine and chemokine expression in response to CoCl2 and H2O2 treatment, and different concentrations of glucose influence this expression under either hypoxic or oxidant-enriched conditions.
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참고문헌 (30)
참고문헌 신청
Friedmann-Morvinski D / 2016 / Targeting NF-kB in glioblastoma: a therapeutic approach / Sci Adv 2:e1501292
Kupp R / 2016 / Lineage-restricted OLIG2-RTK signaling governs the molecular subtype of glioma stem-like cells / Cell Rep 16:2838~2845
McLendon RE / 2003 / Is the long-term survival of patients with intracranial glioblastoma multiforme overstated? / Cancer 98:1745~1748
Puli S / 2006 / Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones / J Neurooncol 79:135~142
Kesari S / 2011 / Understanding glioblastoma tumor biology: the potential to improve current diagnosis and treatments / Semin Oncol (38Suppl 4):S2~S10
Kupp R / 2016 / Lineage-restricted OLIG2-RTK signaling governs the molecular subtype of glioma stem-like cells / Cell Rep 16:2838~2845
McLendon RE / 2003 / Is the long-term survival of patients with intracranial glioblastoma multiforme overstated? / Cancer 98:1745~1748
Puli S / 2006 / Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones / J Neurooncol 79:135~142
Kesari S / 2011 / Understanding glioblastoma tumor biology: the potential to improve current diagnosis and treatments / Semin Oncol (38Suppl 4):S2~S10
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