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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 553 - 559 (7page)
- DOI
- 10.3350/cmh.2021.0127
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초록· 키워드
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The clinical phenotypes of nonalcoholic fatty liver disease (NAFLD) encompass from simple steatosis to nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis or cirrhosis. Liver biopsy has been the standard to diagnose NASH.
However, there has been strong need for precise and accurate noninvasive tests because of invasiveness and sampling variability of biopsy. Metabolomics has drawn attention as a promising diagnostic methodology in the field of NAFLD, particularly to unravel metabolic alterations which plays relevant roles in the progression of NASH. There have been numerous metabolomics researches to find new biomarker of NASH in the last decade, fueled by the recent advances in the metabolomics methodology. This review briefly covers recent research advances on the lipidomics, amino acids and bile acid metabolomics regarding continuing attempts to discover relevant biomarkers for NASH.
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참고문헌 (34)
참고문헌 신청
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
Chalasani N / 2018 / The diagnosis and management of nonalcoholic fatty liver disease : practice guidance from the American Association for the Study of Liver Diseases / Hepatology 67:328~357
Brunt EM / 2021 / NAFLD : reporting histologic findings in clinical practice / Hepatology 73:2028~2038
Verhaegh P / 2018 / Noninvasive tests do not accurately differentiate nonalcoholic steatohepatitis from simple steatosis : a systematic review and metaanalysis / Clin Gastroenterol Hepatol 16:837~861
Dumas ME / 2014 / Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease / Gastroenterology 146:46~62
Chalasani N / 2018 / The diagnosis and management of nonalcoholic fatty liver disease : practice guidance from the American Association for the Study of Liver Diseases / Hepatology 67:328~357
Brunt EM / 2021 / NAFLD : reporting histologic findings in clinical practice / Hepatology 73:2028~2038
Verhaegh P / 2018 / Noninvasive tests do not accurately differentiate nonalcoholic steatohepatitis from simple steatosis : a systematic review and metaanalysis / Clin Gastroenterol Hepatol 16:837~861
Dumas ME / 2014 / Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease / Gastroenterology 146:46~62
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