메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Chen-Hua Liu (Department of Internal Medicine National Taiwan University Hospital) Chi-Yi Chen (Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital) Wei-Wen Su (Division of Gastroenterology Department of Internal Medicine Changhua Christian Hospital) Chun-Jen Liu (National Taiwan University Hospital) Ching-Chu Lo (Department of Internal Medicine St. Martin De Porres Hospital) Ke-Jhang Huang (Department of Internal Medicine China Medical University Beigang Hospital) Jyh-Jou Chen (Chi-Mei Foundation Medical Center) Kuo-Chih Tseng (Dalin Tzu Chi Hospital) Chi-Yang Chang (Department of Internal Medicine Fu Jen Catholic University Hospital) Cheng-Yuan Peng (Center for Digestive Medicine Department of Internal Medicine China Medical University Hospital) Yu-Lueng Shih (Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center) Chia-Sheng Huang (Department of Internal Medicine Yang Ming Hospital) Wei-Yu Kao (Department of Internal Medicine Taipei Medical University Hospital) Sheng-Shun Yang (Department of Internal Medicine Taichung Veterans General Hospital) Ming-Chang Tsai (Department of Internal Medicine Chung Shan Medical University Hospital) Jo-Hsuan Wu (University of California) Po-Yueh Chen (Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital) Pei-Yuan Su (Division of Gastroenterology Department of Internal Medicine Changhua Christian Hospital) Jow-Jyh Hwang (Department of Internal Medicine St. Martin De Porres Hospital) Yu-Jen Fang (Department of Internal Medicine National Taiwan University Hospital) Pei-Lun Lee (Division of Gastroenterology and Hepatology Chi-Mei Medical Center) Chi-Wei Tseng (Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation) Fu-Jen Lee (Department of Internal Medicine Fu Jen Catholic University Hospital) Hsueh-Chou Lai (China Medical University) Tsai‐Yuan Hsieh (Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center) Chun-Chao Chang (Taipei Medical University College of Medicine) Chung-Hsin Chang (Department of Internal Medicine Taichung Veterans General Hospital) Yi-Jie Huang (Department of Internal Medicine Taichung Veterans General Hospital) Jia-Horng Kao (Department of Internal Medicine National Taiwan University Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제4호
발행연도
2021.10
수록면
575 - 588 (14page)
DOI
10.3350/cmh.2021.0155

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/Aims: Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited. Methods: We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR12) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. The safety profiles were reported. Results: The SVR12 rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5?94.2%), 94.1% (95% CI, 87.8?97.3%), and 100% (95% CI, 96.2?100%). Number of patients who failed to achieve SVR12 were attributed to virologic failures. The SVR12 rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR12, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16?14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 m2/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 m2/month; P<0.001). Conclusions: SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis.
#Hepatitis #Chronic #Antiviral agents #Sofosbuvir #Ribavirin #Liver cirrhosis

목차

등록된 정보가 없습니다.

참고문헌 (42)

참고문헌 신청
Lauer GM / 2001 / Hepatitis C virus infection / N Engl J Med 345:41~52 google schola Planas R / 2004 / Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients / J Hepatol 40:823~830 google schola Zarrinpar A / 2013 / Liver transplantation : past, present and future / Nat Rev Gastroenterol Hepatol 10:434~440 google schola Garcia-Retortillo M / 2002 / Hepatitis C virus kinetics during and immediately after liver transplantation / Hepatology 35:680~687 google schola Forman LM / 2002 / The association between hepatitis C infection and survival after orthotopic liver transplantation / Gastroenterology 122:889~896 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0