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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 432 - 439 (8page)
- DOI
- 10.5021/ad.2021.33.5.432
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초록· 키워드
오류제보하기
Background Epidermal growth factor receptor (EGFR) is overexpressed in many cancers. However, EGFR expression in melanoma and its role are conflicting.
Objective This study aimed to evaluate EGFR expression in distant metastatic melanoma and analyze its relationship with histologic and clinical characteristics and survival.
Methods Diagnostic tissues from 55 cases of distant metastatic melanoma was evaluated by immunohistochemistry for EGFR expression. Clinicopathologic features and survival outcomes were analyzed according to EGFR expression.
Results The positive EGFR expression in distant metastatic melanoma was significantly correlated with the absence of ulceration. The EGFR expression in distant metastatic melanoma was significantly associated with poor survival, under the conditions of male sex and primary cutaneous melanoma without ulceration or Breslow thickness ≤4.0 mm. This study bears limitations of a retrospective study in a single institution.
Conclusion EGFR immunostaining had predictive values for survival outcome. The EGFR expression in distant metastatic melanoma in male, no ulcer, or Breslow thickness ≤4.0 mm appeared to be involved in disease progression.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Hynes NE / 2009 / ErbB receptors and signaling pathways in cancer / Curr Opin Cell Biol 21:177~184
Seshacharyulu P / 2012 / Targeting the EGFR signaling pathway in cancer therapy / Expert Opin Ther Targets 16:15~31
Di Domenico M / 2017 / Signal transduction growth factors : the effective governance of transcription and cellular adhesion in cancer invasion / Oncotarget 8:36869~36884
Avruch J / 2001 / Ras activation of the Raf kinase : tyrosine kinase recruitment of the MAP kinase cascade / Recent Prog Horm Res 56:127~155
Yamaguchi H / 2012 / Pathological roles of invadopodia in cancer invasion and metastasis / Eur J Cell Biol 91:902~907
Seshacharyulu P / 2012 / Targeting the EGFR signaling pathway in cancer therapy / Expert Opin Ther Targets 16:15~31
Di Domenico M / 2017 / Signal transduction growth factors : the effective governance of transcription and cellular adhesion in cancer invasion / Oncotarget 8:36869~36884
Avruch J / 2001 / Ras activation of the Raf kinase : tyrosine kinase recruitment of the MAP kinase cascade / Recent Prog Horm Res 56:127~155
Yamaguchi H / 2012 / Pathological roles of invadopodia in cancer invasion and metastasis / Eur J Cell Biol 91:902~907
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