지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.4
- 발행연도
- 2021.10
- 수록면
- 632 - 638 (7page)
- DOI
- 10.5056/jnm20180
이용수
초록· 키워드
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Background/AimsEndoscopic removal of bile duct stones has become the treatment of choice, which includes endoscopic sphincterotomy (EST) in the majority of cases, destroying at least partially the Oddi sphincter (OS). Loss of sphincter function in variable grade has been described, but changes in innervation are not known.
MethodsEndoscopic manometry of OS was performed in 14 patients after EST with specialized perfused catheter. Pressure values were registered before and after 10 mg Buscapina injected intravenously.
ResultsCholedocho-duodenal pressure gradient was absent in all of 14 patients. Basal OS pressure was zero in 7 and conserved in normal range in the remaining 7. Phasic motor activity was registered in 11 patients and was absent in 3 patients. After 10 mg Buscapina intravenous injection, instead of habitual inhibition, increase in basal OS pressure and in frequency of phasic contractions was observed in 9 patients. This response was not related to age of patients, neither with time elapsed between the EST and manometry, nor the estimated size of papillotomy orifice. Duodenal peristalsis was invariably inhibited in all patients.
ConclusionsEST destroys not only the smooth muscle of OS, also alters the innervation interrupting the duodeno-sphincteric nerve circuit. This finding questions the use of Buscapina or other anticholinergic agent as spasmolytic in patients after EST.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Balemba OB / 2004 / Innervation of the extrahepatic biliary tract / Anat Rec A Discov Mol Cell Evol Biol 280:836847
Bosch A / 2007 / The sphincter of Oddi / Dig Dis Sci 52:12111218
Toouli J / 2009 / Sphincter of Oddi : function, dysfunction, and its management / J Gastroenterol Hepatol 24(suppl 3):S57~S62
Woods CM / 2007 / Neurohormonal regulation of the sphincter of Oddi / Curr Gastroenterol Rep 9:165~170
Toouli J / 1991 / Innervation of the sphincter of Oddi : physiology and considerations of pharmacological intervention in biliary dyskinesia / Pharmacol Ther 49:269~281
Bosch A / 2007 / The sphincter of Oddi / Dig Dis Sci 52:12111218
Toouli J / 2009 / Sphincter of Oddi : function, dysfunction, and its management / J Gastroenterol Hepatol 24(suppl 3):S57~S62
Woods CM / 2007 / Neurohormonal regulation of the sphincter of Oddi / Curr Gastroenterol Rep 9:165~170
Toouli J / 1991 / Innervation of the sphincter of Oddi : physiology and considerations of pharmacological intervention in biliary dyskinesia / Pharmacol Ther 49:269~281
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