Adverse events following pediatric immunization in an Indian city

Varun Paramkusham; Prashanth Palakurthy; Navya sri Gurram; Varun Talla; Hunsur Nagendra Vishwas; Venkateshwar Rao Jupally; Satyanarayan Pattnaik

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자료유형: 학술저널

저자정보: Varun Paramkusham (Talla Padmavathi College of Pharmacy) Prashanth Palakurthy (Talla Padmavathi College of Pharmacy) Navya sri Gurram (Talla Padmavathi College of Pharmacy) Varun Talla (Talla Padmavathi College of Pharmacy) Hunsur Nagendra Vishwas (JSS Academy of Higher Education and Research) Venkateshwar Rao Jupally (Talla Padmavathi College of Pharmacy) Satyanarayan Pattnaik (Talla Padmavathi College of Pharmacy)

저널정보: 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.10 No.3

발행연도: 2021.9

수록면: 211 - 216 (6page)

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Purpose: Adverse effects are noticeable immediately after vaccination, especially when vaccinated to healthy people at the time of vaccination. The vaccine may cause adverse events which are very rare but adverse event following immunization surveillance becomes correspondingly more important in a less studied population like India. Hence, there is a need for carrying out a study pertaining to vaccine safety in the pediatric population of age 0?12 years and assessing the events occurring post-vaccination. Materials and Methods: A prospective observational study was conducted in three primary healthcare centers and two tertiary care hospitals for 6 months from April 2016 to September 2016 with a total of 826 children enrolled. Detected adverse events for suspected vaccines were analyzed for causality by the World Health Organization causality assessment instrument. Sex-specific differences in incidences of adverse events were assessed. Results: The cumulative adverse events were found highest in pentavalent vaccines (510 incidences, 62.04%) followed by the bacillus Calmette-Guerin vaccine (189 incidences, 22.99%). The study didn’t reveal any significant association in incidences of adverse events following immunization and sex of the children. Conclusion: Vaccine safety surveillance studies are need of the hour in developing countries to maintain public trust in vaccines, the ultimate objective being to have vaccines with the most favorable benefit-risk profile. The present study discussed the various adverse events following immunization and suggested the absence of any sex-specific difference in incidences of adverse events in children.

#Injection site adverse event #Vaccine #Immunization #Pharmacovigilance #Vaccination #Causality

참고문헌 (23)

참고문헌 신청

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