지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 251 - 267 (17page)
- DOI
- 10.12997/jla.2021.10.3.251
이용수
초록· 키워드
오류제보하기
Chronic inflammation is a hallmark of atherosclerosis and macrophages play a central role in controlling inflammation at all stages of atherosclerosis. In atherosclerosis, macrophages and monocyte-derived macrophages are continuously exposed to cholesterol, oxidized lipids, cell debris, cytokines, and chemokines. Not only do these stimuli induce a specific macrophage phenotype, but they also interact extensively, leading to macrophage heterogeneity in atherosclerotic plaques. Herein, we review the diverse phenotypes of macrophages, the mechanisms underlying macrophage activation, and the contributions of macrophages to atherosclerosis in this context. We also summarize recent studies on foamy macrophages and monocyte-derived macrophages in plaque during disease progression. We provide a comprehensive overview of transcriptional, epigenetic, and metabolic reprogramming of macrophages and discuss the emerging concepts of targeting cytokines and macrophages to modulate atherosclerosis.
목차
등록된 정보가 없습니다.
참고문헌 (106)
참고문헌 신청
Tall AR / 2015 / Cholesterol, inflammation and innate immunity / Nat Rev Immunol 15:104~116
Hansson GK / 2011 / The immune system in atherosclerosis / Nat Immunol 12:204~212
Moore KJ / 2013 / Macrophages in atherosclerosis : a dynamic balance / Nat Rev Immunol 13:709~721
Moore KJ / 2011 / Macrophages in the pathogenesis of atherosclerosis / Cell 145:341~355
Herrington W / 2016 / Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease / Circ Res 118:535~546
Hansson GK / 2011 / The immune system in atherosclerosis / Nat Immunol 12:204~212
Moore KJ / 2013 / Macrophages in atherosclerosis : a dynamic balance / Nat Rev Immunol 13:709~721
Moore KJ / 2011 / Macrophages in the pathogenesis of atherosclerosis / Cell 145:341~355
Herrington W / 2016 / Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease / Circ Res 118:535~546
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
Immune Network
2020 .06
-
Differential Activation of Macrophages Based on Their Environment in Advanced Age
전남의대학술지
2020 .01
-
Triglyceride Regulates the Expression of M1 and M2 Macrophage-specific Markers in THP-1 Monocytes
대한의생명과학회지
2016 .12
-
Comprehensive Lipid Profiling Recapitulates Enhanced Lipolysis and Fatty Acid Metabolism in Intimal Foamy Macrophages From Murine Atherosclerotic Aorta
Immune Network
2023 .08
-
Pro-Inflammatory Role of S1P<sub>3</sub> in Macrophages
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
KLF10 as a regulator of macrophage activation and inflammation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease
지질·동맥경화학회지
2020 .01
-
Application of ex-vivo generated macrophages as potential cell therapy
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Melatonin significantly down-regulates long non-coding RNA Cox2 in M1 macrophages stimulated with LPS
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Transcriptome analysis reveals non-foamy rather than foamy plaque macrophages are proinflammatory in atherosclerotic murine models
한국실험동물학회 학술발표대회 논문집
2019 .01
-
The role of macrophages in gut inflammation
한국실험동물학회 학술발표대회 논문집
2022 .07
-
The regulatory function of Hes1 in metabolic disease related macrophage
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines
Immune Network
2018 .08
-
New Insights Into Tissue Macrophages : From Their Origin to the Development of Memory
Immune Network
2015 .08
-
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages
Immune Network
2021 .04
-
SCAP deficiency in macrophages exacerbates inflammation by promoting M1 macrophage polarization
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Molecular imaging of atherosclerosis using reporter gene system
대한방사성의약품학회지
2018 .01
-
Role of Osteal Macrophages in Bone Metabolism
Journal of Pathology and Translational Medicine
2015 .01
-
In vitro cultivation system that mimics the monocyte-macrophages waterfall in the gut
한국실험동물학회 학술발표대회 논문집
2023 .02
-
[S3-2] Regulation of macrophage activation in cardiovascular diseases
한국실험동물학회 학술발표대회 논문집
2024 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0