지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 132 - 140 (9page)
- DOI
- 10.6118/jmm.21016
이용수
초록· 키워드
오류제보하기
Objectives: Menopause induces changes in neuronal transmission, leading to anxiety and depression. Changes in the brain’s glutamate levels cause psychological behavior in postmenopausal women. Omega-3 has been studied to improve some of these behaviors. Methods: Twenty-four female Wistar rats were divided into four groups: sham-operated treated with water (SO-W), sham-operated treated with omega-3 (SO-O), ovariectomized (OVX) treated with water (OVX-W), and bilateral OVX treated with omega-3 (OVX-O). These treatments were performed for 20 days via gavage, before and after surgery, totaling 40 days. Results: In the forced swimming, elevated plus-maze, and open field tests to assess behaviors, such as depression and anxiety, omega-3 improved these behaviors in both treated groups. The levels of thiobarbituric acid reactive substances (TBARS) in the brain were not different between the groups; however, there was a significant decrease in the catalase activity in the SO-O group compared with the SO-W group (P < 0.05). The glutamate level in the cerebrospinal fluid (CSF) was elevated in the SO-O group (P < 0.001) but not in the OVX-W or OVX-O groups.Conclusions: These results bring novel data when related to the glutamatergic system in the SO-O group. This has suggested that the action mechanism of omega-3 was not dependent on glutamate levels in the CSF of the OVX group, but it played a regulatory role in the sham-operated animals. To confirm this, more studies are needed to explore this field when relating to the estrogen and glutamate receptor changes in specific brain regions.
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등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Pınar ŞE / 2015 / A problem peculiar to women : mental health in menopause / J Hum Sci 12:787~798
Campos GV / 2020 / The angiotensin type 1 receptor antagonist losartan prevents ovariectomy-induced cognitive dysfunction and anxiety-like behavior in long evans rats / Cell Mol Neurobiol 40:407~420
Wada T / 2018 / Impact of central and peripheral estrogen treatment on anxiety and depression phenotypes in a mouse model of postmenopausal obesity / PLoS One 13:e0209859
Izumo N / 2021 / Lactoferrin suppresses decreased locomotor activities by improving dopamine and serotonin release in the amygdala of ovariectomized rats / Curr Mol Pharmacol 14:245~252
Lipsitz O / 2021 / Intravenous ketamine for postmenopausal women with treatment-resistant depression : results from the Canadian Rapid Treatment Center of Excellence / J Psychiatr Res 136:444~451
Campos GV / 2020 / The angiotensin type 1 receptor antagonist losartan prevents ovariectomy-induced cognitive dysfunction and anxiety-like behavior in long evans rats / Cell Mol Neurobiol 40:407~420
Wada T / 2018 / Impact of central and peripheral estrogen treatment on anxiety and depression phenotypes in a mouse model of postmenopausal obesity / PLoS One 13:e0209859
Izumo N / 2021 / Lactoferrin suppresses decreased locomotor activities by improving dopamine and serotonin release in the amygdala of ovariectomized rats / Curr Mol Pharmacol 14:245~252
Lipsitz O / 2021 / Intravenous ketamine for postmenopausal women with treatment-resistant depression : results from the Canadian Rapid Treatment Center of Excellence / J Psychiatr Res 136:444~451
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