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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 156 - 162 (7page)
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Estrogen receptor ? (ER-?), which is involved in bone metabolism and breast cancer, has been shown to have transcriptional targets. Dlx3 is essential for the skeletal development and plays an important role in osteoblast differentiation. Various osteogenic stimulators and tran-scription factors can induce the protein expression of Dlx3. However, the regulatory function of ER-? in the Dlx3 mediated osteogenic process remains unknown. Therefore, we investigated the regulation of Dlx3 and found that ER-? is a positive regulator of Dlx3 transcription in BMP2-induced osteoblast differentiation. We also found that ER-? interacts with Dlx3 and increases its transcriptional activity and DNA binding affinity. Furthermore, we demonstrated that the regulation of Dlx3 activity by ER-? is independent of the ligand (estradiol) binding domain. These results indicate that Dlx3 is a novel target of ER-?, and that ER-? regu-lates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3.
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참고문헌 (45)
참고문헌 신청
Bjornstrom, L. / 2002 / Mutations in the estrogen receptor DNA-binding domain discriminate between the classical mechanism of action and cross-talk with Stat5b and activating protein 1(AP-1) / J. Biol. Chem 277:48479~48483
Chang, W. / 2005 / Interactions between CCAAT enhancer binding protein delta and estrogen receptor alpha control insulin-like growth factor I(igf1)and estrogen receptor-dependent gene expression in osteoblasts / Gene 345:225~235
Chen, T. K. / 1996 / Activation and inhibition of the AP-1 complex in human breast cancer cells / Mol. Carcinog 15:215~226
Choi, S. J. / 2008 / A 4 bp deletion mutation in DLX3 enhances osteoblastic differentiation and bone formation in vitro / Bone 42:162~171
Choi, S. J. / 2009 / In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development / Dev. Biol 325:129~137
Chang, W. / 2005 / Interactions between CCAAT enhancer binding protein delta and estrogen receptor alpha control insulin-like growth factor I(igf1)and estrogen receptor-dependent gene expression in osteoblasts / Gene 345:225~235
Chen, T. K. / 1996 / Activation and inhibition of the AP-1 complex in human breast cancer cells / Mol. Carcinog 15:215~226
Choi, S. J. / 2008 / A 4 bp deletion mutation in DLX3 enhances osteoblastic differentiation and bone formation in vitro / Bone 42:162~171
Choi, S. J. / 2009 / In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development / Dev. Biol 325:129~137
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