지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제1호
- 발행연도
- 2023.1
- 수록면
- 43 - 50 (8page)
- DOI
- 10.4014/jmb.2207.07017
이용수
초록· 키워드
오류제보하기
Fungal keratitis is a refractory kind of keratopathy. We attempted to investigate the antiinflammatory role of thymol on Aspergillus fumigatus (A. fumigatus) keratitis. Wound healing and fluorescein staining of the cornea were applied to verify thymol’s safety. Mice models of A. fumigatus keratitis underwent subconjunctival injection of thymol. The anti-inflammatory roles of thymol were verified by hematoxylin-eosin (HE) staining, slit lamp observation, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting. In contrast with the DMSO group, more transparent corneas and less inflammatory cells infiltration were detected in mice treated with 50 μg/ml thymol. Thymol downregulated the synthesis of TLR4, MyD88, NF-kB, IL-1β, NLRP3, caspase 1, caspase 8, GSDMD, RIPK3 and MLKL. In summary, we proved that thymol played a protective part in A. fumigatus keratitis by cutting down inflammatory cells aggregation, downregulating the TLR4/ MyD88/ NF-kB/ IL-1β signal expression and reducing necroptosis and pyroptosis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Aspergillus fumigatus 에 의한 휘발성유기화합물 분해
한국대기환경학회 학술대회논문집
2017 .11
-
Role of Signal Peptidase in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2022 .10
-
Slit-lamp Examination of Mycotic Keratitis
대한의진균학회지
2017 .01
-
Expression Patterns of Developmental Genes during Mating in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2019 .04
-
진균각막염의 임상양상 및 치료실패의위험인자에 관한 분석
대한의진균학회지
2015 .01
-
Iron and Copper Metabolisms are Closely Connected and Interdependent; Look into Their Relationship in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2018 .04
-
Zinc Regulates Gliotoxin Biosynthesis in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2020 .10
-
Zinc Regulates Gliotoxin Biosynthesis in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2019 .04
-
LAMMER Kinase is Regulator of Virulence Factors in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2021 .08
-
Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway
Genes & Genomics
2021 .08
-
LAMMER Kinase Affects PAMP Expression and Virulence in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2021 .08
-
LAMMER Kinase is a Positive Regulator for Differentiation and Biofilm Formation of Aspergillus fumigatus
한국미생물학회 학술대회논문집
2021 .08
-
Effects of TLR9/NF-κB on oxidative stress and inflammation in IPEC-J2 cells
Genes & Genomics
2022 .10
-
Differentiation and Virulence of Aspergillus fumigatus Velvet A (VeA) Mutant
한국미생물학회 학술대회논문집
2022 .10
-
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages
Genes & Genomics
2024 .03
-
Functional Analysis of vosA, a Velvet Protein Gene, on Sexual Development and Virulence in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2022 .10
-
A Putative Signal Peptidase AfSec11 is Involved in Caspofungin Resistance in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2020 .10
-
The early induction of suppressor of cytokine signaling 1 and the downregulation of toll-like receptors 7 and 9 induce tolerance in costimulated macrophages
Molecules and Cells
2015 .01
-
The Aspergillus fumigatus AfundrA Gene Encodes HLH Transcription Factor, Which is Required for Conidiation
한국미생물학회 학술대회논문집
2015 .04
-
Identification and Characterization of SrbB, a New Sterol Regulatory Element Binding Protein Involved in Regulation of the Hypoxia Response and Virulence in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2015 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0