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논문 기본 정보

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학술저널
저자정보
Won Ha-Kyeong (Division of Pulmonology and Allergy Department of Internal Medicine Veterans Health Service Medical Center Seoul Korea.) Song Woo-Jung (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Moon Sung do (Department of Internal Medicine Hospital Medicine Center Seoul National University Hospital Seoul Korea.) Sohn Kyoung-Hee (Department of Internal Medicine Kyung Hee University Medical Center Seoul Korea.) Kim Ju-Young (Department of Internal Medicine Dankook University Hospital Cheonan Korea.) Kim Byung-Keun (Division of Pulmonology Allergy and Critical Care Medicine Department of Internal Medicine Korea University College of Medicine Seoul Korea.) Park Heung-Woo (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center Seoul Korea.) Bachert Claus (Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University Ghent Belgium.) Cho Sang Heon (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center Seoul Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.2
발행연도
2023.3
수록면
160 - 173 (14page)
DOI
10.4168/aair.2023.15.2.160

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Purpose: Staphylococcus aureus enterotoxin-specific immunoglobulin E (SE-sIgE) sensitization tends to increase with age and is known to be associated with asthma and severity in older adults. However, the long-term impact of SE-sIgE in the elderly remains unknown. This study aimed to examine the relationships between SE-sIgE and fixed airflow obstruction (FAO) in a cohort of elderly asthmatics. Methods: A total of 223 elderly asthmatics and 89 controls were analyzed. Patients were assessed for demographics, history of chronic rhinosinusitis (CRS), asthma duration, acute exacerbation frequency, and lung function at baseline and then were prospectively followed up for 2 years. Serum total IgE and SE-sIgE levels were measured at baseline. Airflow obstruction was defined as forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7 at baseline and FAO was defined as FEV1/FVC ratio < 0.7 over the 2-year follow-up. Results: At baseline, the prevalence of airflow obstruction was 29.1%. Patients with airflow obstruction were significantly more likely to be male, and have a positive smoking history, comorbid CRS, and higher levels of SE-sIgE than those without airflow obstruction. Multivariate logistic regression analysis showed that airflow obstruction was significantly associated with current smoking and SE-sIgE sensitization at baseline. After the 2-year follow-up, baseline SE-sIgE sensitization was consistently related to FAO. Meanwhile, the number of exacerbations per year was significantly correlated with SE-sIgE levels. Conclusions: Baseline SE-sIgE sensitization was significantly associated with the number of asthma exacerbations and FAO after the 2-year follow-up in elderly asthmatics. These findings warrant further investigation of the direct and mediating roles of SE-sIgE sensitization on airway remodeling.
#Asthma #immunoglobulin E #enterotoxins #Staphylococcus aureus

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