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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.11
- 수록면
- 353 - 358 (6page)
- DOI
- 10.17519/apiculture.2023.11.38.4.353
이용수
초록· 키워드
오류제보하기
Influenza viruses are responsible for respiratory infections in humans, which results in significant morbidity and mortality. Among the drugs commonly employed to treat influenza virus infections, neuraminidase inhibitors, such as oseltamivir and peramivir, feature prominently. However, the emergence of drug-resistant viruses underscores the need for the development of new anti-influenza medications. Korean Native bee-honey has been used for medicinal and food. Korean native bee-honey exhibits pharmacological effects, including antioxidant, anti-inflammatory, and antimicrobial activity; however, an anti-influenza effect of Korean native bee-honey has not been reported. In this study, we determined whether Korean native bee-honey from nine different regions (samples A-I) exhibits antiviral activity in pre-, co-, and posttreatment assays using the green fluorescent protein (GFP)-tagged influenza
A/PR/8/34 (A/PR/8/34-GFP) virus. The results indicated that sample G (native bee-honey in Nonsan-si, Chungcheongnam-do) exhibited inhibitory effects in the pre-treatment assay against IAV. Also, samples C (native bee-honey in Boseong-gun, Jeollanam-do) and H (native bee-honey in Muju-gun, Jeollabuk-do) had anti-influenza effect under co-treatment conditions, and samples D (native bee-honey in Gapyeong-gun, Gyeonggi-do) and F (native bee-honey in Hamyang-gun, Gyeongsangnam-do) showed antiviral activity under post-treatment conditions. These results warrant further studies to identify the active ingredients and mechanisms underlying the antiinfluenza effect of Korean native bee-honey.
A/PR/8/34 (A/PR/8/34-GFP) virus. The results indicated that sample G (native bee-honey in Nonsan-si, Chungcheongnam-do) exhibited inhibitory effects in the pre-treatment assay against IAV. Also, samples C (native bee-honey in Boseong-gun, Jeollanam-do) and H (native bee-honey in Muju-gun, Jeollabuk-do) had anti-influenza effect under co-treatment conditions, and samples D (native bee-honey in Gapyeong-gun, Gyeonggi-do) and F (native bee-honey in Hamyang-gun, Gyeongsangnam-do) showed antiviral activity under post-treatment conditions. These results warrant further studies to identify the active ingredients and mechanisms underlying the antiinfluenza effect of Korean native bee-honey.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
CONCLUSION
LITERATURE CITED
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