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논문 기본 정보

자료유형
학술저널
저자정보
Soo Min Kim (Home Beauty Development Team, Home Appliance & Air Solution, LG Electronics, Seoul, Republic of Korea) Tae-Rin Kwon (Home Beauty Development Team, Home Appliance & Air Solution, LG Electronics, Seoul, Republic of Korea) Dong Wook Moon (Home Beauty Development Team, Home Appliance & Air Solution, LG Electronics, Seoul, Republic of Korea) Jungwook Kim (Home Beauty Development Team, Home Appliance & Air Solution, LG Electronics, Seoul, Republic of Korea) Rae Hyun Lim (Home Beauty Development Team, Home Appliance & Air Solution, LG Electronics, Seoul, Republic of Korea) Jungkwan Lee (Home Beauty Development Team, Home Appliance & Air Solution, LG Electronics, Seoul, Republic of Korea) So Young Lee (Department of Dermatology, Chung-Ang University Hospital, Seoul, Republic of Korea) Ka Ram Kim (Department of Dermatology, Chung-Ang University Hospital, Seoul, Republic of Korea) Young Gue Koh (Department of Dermatology, Chung-Ang University Hospital, Seoul, Republic of Korea) Hye Sung Han (Department of Dermatology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea) Sun Young Choi (Department of Dermatology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea) Kwang Ho Yoo (Department of Dermatology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea)
저널정보
대한의학레이저학회 MEDICAL LASERS Medical Lasers Vol.13 No.1
발행연도
2024.3
수록면
35 - 46 (12page)
DOI
10.25289/ML.24.004

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초록· 키워드

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Background: We aimed to clarify the safety and efficacy of simultaneous skin exposure to blue, red, and infrared light. The purpose of this study was to confirm the mechanism by which multiple wavelengths increase hair development both in vivo and in vitro.Methods: Cultured human dermal papilla cells (hDPCs) were exposed to a 470/655/850 nm light-emitting diode (LED) array with a fixed energy density of 3.0 mW/cm2. We analyzed alkaline phosphatase (ALP) staining and activity. The relative expressions of ALP, VEGF, Shh, and OPN3 were examined using reverse transcriptase-polymerase chain reaction arrays 48 hours post-exposure and the protein levels related to extracellular signal-regulated kinase (ERK)/protein kinase B (AKT)/glycogen synthase kinase 3 (GSK3)β signaling were assessed by western blotting. Next, we used H&E staining, hair growth scoring, skin thickness measurement, and the immunohistochemical analysis of the dorsal skin of C57BL/6 mice to investigate the effects of the mono- or combined-photobiomodulation (PBM) groups.Results: According to our findings, simultaneous irradiation with multi-wavelength LEDs at 470/655/850 nm increased the proliferation of hDPCs. Also, compared to the control group, the red wavelength and combined PBM groups had significantly improved skin thickness measurements. Overall, we concluded that the combined PBM therapy successfully induced the early onset of anagen and stimulated hair growth.Conclusion: These results suggest that PBM therapy regulates hair growth by activating the ERK/AKT/GSK3β signaling pathway. Thus, multiple-wavelength radiation from devices combining radiation emitted by low-power lasers and LEDs could be a new approach for promoting PBM-induced beneficial effects.

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