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논문 기본 정보

자료유형
학술저널
저자정보
Hironori Nakagami (Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Suita, Japan.) Hiroki Hayashi (Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Suita, Japan.) Ryuichi Morishita (Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan)
저널정보
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 Journal of Lipid and Atherosclerosis Vol.13 No.3
발행연도
2024.9
수록면
328 - 337 (10page)
DOI
10.12997/jla.2024.13.3.328

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초록· 키워드

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To combat the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), novel vaccine modalities, such as messenger RNA vaccines, were rapidly developed and have shown high efficacy. This new vaccine technology, underpinned by intensive immunological analysis, is now being applied to the production of other vaccines. For over 10 years, we have been developing therapeutic vaccines for non-infectious diseases. The epitope vaccine approach, which combines a B-cell epitope with exogenous T-cell epitopes presented through major histocompatibility complex molecules, has been proposed to induce antibody production. This vaccine type is designed to efficiently induce a blocking antibody response against the self-antigen without activating cytotoxic T cells. If therapeutic vaccines become established as treatment options for conditions such as hypertension or dyslipidemia, their administration—potentially only a few times per year—could replace the need for daily medication. Nucleic acid drugs, including small interfering RNA and antisense oligonucleotides, have recently received attention as long-term agonists, similar to vaccines. Therefore, therapeutic vaccines or nucleic acid drugs could represent a novel strategy for controlling the progression of cardiovascular diseases. It is hoped that the accumulation of immunological findings and advances in vaccine technology will provide valuable insights into the development of vaccines for treating cardiovascular diseases.

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