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논문 기본 정보

자료유형
학술저널
저자정보
Park Kee Hyung (Department of Neurology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.) Kim Geon Ha (Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.) Kim Chi-Hun (Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.) Koh Seong-Ho (Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.) Moon So Young (Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.) Park Young Ho (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.) Seo Sang Won (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Yoon Bora (Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Lim Jae-Sung (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Byeong C. (Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.) Kim Hee-Jin (Department of Neurology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea.) Na Hae Ri (Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.) Shim YongSoo (Department of Neurology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Yang YoungSoon (Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.) Lee Chan-Nyoung (Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.) Rhee Hak Young (Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.) Jung San (Department of Neurology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.) Jeong Jee Hyang (Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.) Choi Hojin (Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.) Yang Dong Won (Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Choi Seong Hye (Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.)
저널정보
대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제23권 제4호
발행연도
2024.11
수록면
165 - 187 (23page)
DOI
10.12779/dnd.2024.23.4.165

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초록· 키워드

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Lecanemab (product name Leqembi®) is an anti-amyloid monoclonal antibody treatment approved for use in Korea for patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease. The Korean Dementia Association has created recommendations for the appropriate use of lecanemab to assist clinicians. These recommendations include selecting patients for administration, necessary pre-administration tests and preparations, administration methods, monitoring for amyloid related imaging abnormalities (ARIA), and communication with patients and caregivers. Lecanemab is recommended for patients with MCI or mild dementia who confirmed positive amyloid biomarkers, and should not be administered to patients with severe hypersensitivity to lecanemab or those unable to undergo magnetic resonance imaging (MRI) evaluation. To predict the risk of ARIA before administration, apolipoprotein E genotyping is conducted, and regular brain MRI evaluations are recommended to monitor for ARIA during treatment. The most common adverse reactions are infusion-related reactions, which require appropriate management upon occurrence. Additional caution is needed when co-administering with anticoagulants or tissue plasminogen activator due to the risk of macrohemorrhage. Clinicians should consider the efficacy and necessary conditions for administration, as well as the safety of lecanemab, to make a comprehensive decision regarding its use.
#Lecanemab #Alzheimer's Disease #Amyloid #Magnetic Resonance Imaging #Monoclonal Antibody

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