인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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초록·키워드
The aim of this study was to develop novel biomedicated electrospun nanofiber for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate(2 wt.%) (SA)/polyvinyl alcohol(10 wt.%) (PVA) (2:8, 3:7 and 1:9) composites by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy. The optimum ratio(3:7) was used for loading of gatifloxacin hydrochloride (GH) (1wt.%), found to form smooth fibers with uniform structures. The drug entrapment, in the composite nanofibers was confirmed by scanning electron microscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA),differential scanning calorimetry (DSC) and swelling behavior. The drug release behavior was investigated by using phosphate buffered saline (PBS) (pH 7.4) at 37°C for 24hrs. XRD and FT-IR data demonstrates that there are good interactions between PVA and SA caused by possibly hydrogen bonds. As much as 90 % of the GH was released from the electrospun fibers within 6hrs of incubation, beyond this the release was sustained for 24hrs. The thickness of nanofibers greatly influenced the initial release and rate of drug release. Moreover, GH loaded sodium alginate / PVA composite nanofibers exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications.
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최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2018-505-001065913
