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초록·키워드
We have synthesized 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin as a new imaging agent for hepatobiliary scintigraphy. The aim of this study was to evaluate the usefulness of 99mTc-MAG3-biocytin scintigraphy in differentiating carbon tetrachloride (CCl₄)-induced hepatotoxicity from a-naphthylisothiocyanate (ANIT)-induced cholestasis in mice, which reflecting the differential diagnosis of neonatal jaundice caused by neonatal hepatitis from congenital biliary atresia in humans. Methods: Balb/c mice (female, 20 g, n=4-6) were pretreated with CCl4 (0.5 or 1.0 ml/kg) and ANIT (150 or 300 mg/kg) 18 h before scintigraphy. Biochemical and histopathological examinations showed a pattern of typical acute hepatitis (increase of transaminases and hepatocellular necrosis) in CCl4-treated mice and cholestasis (increase of alkaline phosphatase and g-glutamyltransferase, and biliary hyperplasia) in ANIT-treated mice, respectively. Mice were fasted at least 4 hr prior to the intravenous injection of 99mTc-MAG3-biocytin (18.5 MBq/ 20㎍) in 2% human serum albumin in saline. Scintigraphy
was performed with a g-camera equipped with a 1-mm diameter pin-hole collimator for 30 min and images were acquired every 15 s. We compared the values of physical parameters, such as peak liver/heart ratio (rmax) and peak ratio time (tmax) for 99mTc-MAG3-biocytin scintigraphy. Results: Scintigraphic parameters of the
CCl₄-pretreated (0.5 ml/kg) group showed a 81.9% decrease of rmax, and 42.2% decrease of tmax, whereas the ANIT-pretreated (150 mg/kg) group showed a 53% decrease of rmax, and 2.36-fold increase of tmax, (P<0.05). These results demonstrate that the decrease of rmax and the shortening of tmax are characteristic features for
hepatotoxicity, in contrast to the increase of tmax and decrease of rmax for biliary hyperplasia. Conclusion: 99mTc-MAG3-biocytin hepatobiliary scintigraphy can distinguish hepatitis from cholestasis in mice model and may be similarly useful in humans which differentiating the cause of neonatal jaundice in clinical study.
was performed with a g-camera equipped with a 1-mm diameter pin-hole collimator for 30 min and images were acquired every 15 s. We compared the values of physical parameters, such as peak liver/heart ratio (rmax) and peak ratio time (tmax) for 99mTc-MAG3-biocytin scintigraphy. Results: Scintigraphic parameters of the
CCl₄-pretreated (0.5 ml/kg) group showed a 81.9% decrease of rmax, and 42.2% decrease of tmax, whereas the ANIT-pretreated (150 mg/kg) group showed a 53% decrease of rmax, and 2.36-fold increase of tmax, (P<0.05). These results demonstrate that the decrease of rmax and the shortening of tmax are characteristic features for
hepatotoxicity, in contrast to the increase of tmax and decrease of rmax for biliary hyperplasia. Conclusion: 99mTc-MAG3-biocytin hepatobiliary scintigraphy can distinguish hepatitis from cholestasis in mice model and may be similarly useful in humans which differentiating the cause of neonatal jaundice in clinical study.
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UCI(KEPA) : I410-ECN-0101-2009-476-013746848
