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Experimental Evidences and Functional Hypothesis of Acupuncture Mechanisms

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Experimental Evidences and Functional Hypothesis of Acupuncture Mechanisms
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    초록·키워드

    Acupuncture therapy has demonstrated efficacy in several clinical areas, and of these areas the understanding of pain has progressed immensely in the last two decades. The underlying mechanisms of acupuncture in general and the analgesic effect in particular are, however, still not clearly delineated. The leading hypotheses include the effects of local stimulation, neuronal gating, release of endogenous opiates, and the placebo effect. Accumulating evidence suggests that the central nervous system (CNS) is essential for the processing of these effects, via its modulation of the autonomic nervous system, neuro-immune system, and hormonal regulation. These processes tap into basic survival mechanisms. As such, understanding the effects of acupuncture within a neuroscience-based framework becomes vital. We propose a model, termed as a broad sense hypothalamus-pituitary-adrenal (BS-HPA) axis based on our observed neuroimaging results, which incorporates the stress-induced HPA axis model together with neuro--immunce interaction including the cholinergic anti-inflammatory model.

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      UCI(KEPA) : I410-ECN-0101-2009-187-017110577