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지원사업
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커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
??This study was designed to examine the effects of fractions of ethanol extract of Benincasa hispida (wax gourd) on hepatic antioxidative status in streptozotocin (STZ) induced diabetic rats. Sprague-Dawley rats were induced diabetes mellitus by STZ injection (45 ㎎/㎏) into the tail vein and were divided into 5 groups: normal, STZ-control, three experimental diabetic groups. Fractions of ethanol extract of Benincasa hispida were administered orally into the diabetic rats for 14 days. Hepatic glutathione peroxidase (GSH-px) activity (determined with H₂O₂ as substrate) was increased in the groups supplemented with chloroform (CHCl₃) and butanol (BuOH) fractions. Glutathione peroxidase (GR) activity in the liver cytosol of H₂O fraction groups was significantly lower than that of STZ-control group. The H₂O fraction supplemented group has been shown the notably decrease in the hepatic superoxide dismutase (SOD) activity. The hepatic cytosol catalase (CAT) activity was significant decreased by the supplementation with BuOH fraction. It was found from the results that the supplementation of BuOH and H₂O fractions of Benincasa hispida extract could be beneficial for the diabetic complications and damages from the lipid peroxidation. (Korean J Nutr 2007; 40 (4): 295~302)
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UCI(KEPA) : I410-ECN-0101-2012-594-004192054
