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(고려대학교) (고려대학교) (성균관대학교) (University of California) (University of California) (고려대학교)
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한국미생물학회 한국미생물학회 학술대회논문집 2007년도 International Meeting of the Microbiological Society of Korea, May
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    초록·키워드

    The subjects of our research are a group of gammaherpesviruses which are associated with malignancies. Epstein-Barr virus (EBV) is associated with endemic Burkitt's lymphoma, Hodgkin's lymphoma, nasopharyngeal carcinoma, and lymphoproliferative diseases in immune deficient patients (1); Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8 is associated with Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (2). The cause of these malignancies stems from the capacity of gammaherpesviruses to establish latent infection and evade from host immune surveillance besides transforming activities of certain viral genes. Due to limited host ranges of human gammaherpesviruses, we take advantage of murine gammaherpesvirus 68 (MHV-68 or γHV-68), whose genomic arrangement and biological properties are closely related to KSHV and EBV, as a small animal model system to study the interactions of tumor-associated herpesviruses with the host and ... 전체 초록 보기

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