인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 저자정보
피인용 0
초록·키워드
Wrinkles are an outward sign of cutaneous aging appearing preferentially on ultraviolet B (UVB)-exposed areas. The anti-wrinkle effects of herbal extracts were investigated in an animal model. The female albino hairless mice (HR/ICR) were randomly allocated to the control group (non irradiated-vehicle), positive control group (UVB irradiated-vehicle) and two herbal extract mixture groups (HE-1 and HE-2). HE-1 included Glycyrrhizae radix, Rhei Rhizoma, Cornus officinalis, and Sesami semeni and HE-2 included Swertia pseudo-chinensis, Sophora flavescens, Scutellaria baicalensis, and Salvia miltiorrhiza. The herbal extract mixtures were pre-treated dorsally with 0.2 ml per individual five times a week for 4 weeks in advance to the beginning of UVB irradiation. At fifth week, the animals were exposed to UVB irradiation for subsequent 8 weeks three times a week. The intensity of irradiation was gradually increased from 30 mJ/cm2 to 240 mJ/cm² (1 MED: 60 mJ/cm²). Dorsal skin samples were stained with H&E to examine the epidermal thickness. The amount of collagen fiber was also determined by Masson-Trichrome staining. The treatments of the HE-1 & 2 showed an increased collagen fiber amount, a better appearance, and less wrinkle, compared with the positive control. As determined by hydroxyproline assay, the treatments of the HE-1 & 2 significantly increased the collagen amount, compared with the positive control group (p<0.05). The chronic UVB irradiation to hairless mice skin increased expression of matrix metalloproteinase-1 (MMP-1) but the treatments of HE-1 & 2 tended to decrease the expression of MMP-1. These results indicate that the herbal extracts used in this study have a preventive effect on the UVB-induced wrinkle formation in hairless mice model, partly due to the inhibition of MMP-1 expression and increment of collagen amount.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2013-528-002902643
