메뉴 건너뛰기
소속 기관 / 학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
고객센터 ENG
주제분류

논문 기본 정보

저자정보
(Korea University) (Korea University) (Korea Institute of Science and Technology) (Korea Institute of Science and Technology) (Korea University)
저널정보
한국실험동물학회 한국실험동물학회 학술발표대회 논문집 2015년 한국실험동물학회 국제학술대회
오류 신고하기

피인용 0

검색

    초록·키워드

    We previously demonstrated that human bone marrow mesenchymal stem cells (hBMSCs) can be induced to undergo chondrogenesis by small molecules. Additionally, it was found that control of cytoskeleton activity via Rho-ROCK promotes the chondrogenic differentiation of MSCs. Specially, cartilage formation proceeds through condensation of mesenchymal cells. The control of cytoskeleton activity via Pasteurella multocida toxin (PMT) may aggregate cells within the condensation center. PMT activates a range of intracellular signaling pathways including Rho-ROCK. Therefore, we determined that the activation of Rho-ROCK pathway by PMT can influence chondrogenic differentiation of MSCs in the presence of TGF-β3 and small molecules. For initiating chondrogenesis, a mechanical force by centrifugation with 10 ng/mL PMT formed 3Dimension cell clusters and clusters were cultur ... 전체 초록 보기

    최근 본 자료 전체보기

      UCI(KEPA) : I410-ECN-0101-2016-528-001957868