인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 저자정보
피인용 0
초록·키워드
The human gammaherpesviruses, Epstein-Barr Virus (EBV) and Kaposi’s Sarcoma Associated Herpesvirus (KSHV) can establish long-term latent infections that drive cellular proliferation and carcinogenesis. Viral genomes and gene products are consistently detected in cancers of various lymphoid and epithelial cell origin. EBV is associated with endemic forms of nasopharyngeal carcinoma and Burkitt’s lymphoma, and sporadic forms of gastric carcinoma, Hodgkin’s disease, B-cell lymphoma, NK-T cell lymphoma, and lymphoproliferative diseases of the immunosuppressed. KSHV is associated with all forms of KS, pleural effusion lymphomas, and Castlemen’s disease. The pathogenesis depends on the ability of the viral genomes to establish and maintain a latent infection in long-term proliferating cells. Our lab has focused on the molecular chromosome biology of the latent viral genomes.
Both EBV and KSHV persist in B-lymphocytes as multicopy, chromatin-associated episomes. They enter cells as nucleosome-free, linear DNA but rapidly acquire a chromatin structure that is competent for transcription, replication, and mitotic chromosome segregation mediated by host cell machinery. The mechanisms that control this epigenetic process are not completely understood, but essential for viral persistence, and potential novel targets for therapeutic intervention. Both viruses maintain their genomes through a centromere-like maintenance element that is bound by a viral encoded maintenance protein. EBV encoded EBNA1 and KSHV encoded LANA are DNA binding proteins with similar structural and functional properties. EBNA1 and LANA bind to multiple, repetitive elements and block replication fork ... 전체 초록 보기
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2017-475-001058368
