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(Duke University) (University of Aberdeen) (University of Aberdeen) (University of Aberdeen) (Duke University) (Duke University)
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한국미생물학회 한국미생물학회 학술대회논문집 2016년도 International Meeting of the Microbiological Society of Korea
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    초록·키워드

    The host-pathogen interface is an important base in establishment of infections by pathogenic microbes and understanding these processes provides a fundamental forum to develop therapeutic interventions. Although mucormycosis, an infection caused by mucoralean fungi, is emerging and continuing to increase due to increasing cohorts of immunocompromised patients, our knowledge about host-pathogen interactions in mucormycosis is as yet in its infancy. The causal fungi include Mucor spp., Rhizopus spp., Lichtheimia spp., and others, among which this study focuses on Mucor circinelloides. Interestingly, Mucor is a dimorphic fungus and its morphogenic transition between spores/hyphae and yeast depends on environmental conditions. We found that the spores/hyphae are more virulent form of this fungus; in contrast, yeast-locked mutants display significantly diminished virulence. In this study, we further demonstrate that the dimorphic transition of Mucor programs differe ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2017-475-001042151