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(Seoul National University) (Korean National Institute of Health) (Seoul National University) (Seoul National University) (Seoul National University) (Seoul National University) (Konyang University) (Seoul National University)
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한국미생물학회 한국미생물학회 학술대회논문집 2015년도 International Meeting of the Microbiological Society of Korea
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    초록·키워드

    Gram-positive bacteria contain lipoteichoic acid (LTA) and peptidoglycan (PGN), both of which are known as major virulence factors for inflammation. Cyclooxygenase-2 (COX-2) plays an important role in the inflammation by generating prostaglandins at infections. Since LTA and PGN are thought to cooperate in the establishment of inflammation, we examined the ability of staphylococcal LTA (Sa.LTA) to induce COX-2 expression in the presence of muramyl dipeptide (MDP), which is the minimal structural unit of PGN required for inflammation, in macrophages. Sa.LTA alone induced COX-2 production at both the p ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2017-475-001048264