메뉴 건너뛰기
소속 기관 / 학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
고객센터 ENG
주제분류

피인용 0

검색

    초록·키워드

    We have previously shown that an initial manifestation of the nephrotoxicity induced by gasoline is an accumulation of a male rat-specific protein, a_2u-globulin, and hyalin (protein resorption) droplets in epithelial cells of the renal proximal convoluted tubules (PCT). The present studies were performed to determine whether a dose-response relationship exists for gasoline-induced accumulation of hyalin droplets and a_2u-globulin in the kidney. Male rats were treated with 0.0004-1.0 mL unleaded gasoline/kg orally for nine days. There was a dose-dependent elevation of renal a_2u-globulin content only in the range 0.04-1.0 mL/kg with no effect on hepatic a_2u-globulin at any dose. Doses less than 0.04 mL/kg did not have any effect on the renal content of a_2u-globulin. However, a significant (150% of control) increase in the a_2u-globulin content was seen after 0.04 mL/kg. This increase was further augmented from 200% to 40 ... 전체 초록 보기

    최근 본 자료 전체보기

      UCI(KEPA) : I410-ECN-0101-2009-556-014124443