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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 965 - 970 (6page)
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초록· 키워드
Oleuropein content of olive leaf extracts (OLE; ethanol extract) was evaluated by high performance liquid chromatography analysis. Oleuropein contents were 4.21±0.57, 3.92±0.43, 0.32±0.03, 5.76±0.32, and 32.47±0.25 ㎎/100 g for ethanol extract, and hexane, chloroform, ethyl acetate, and butanol fraction, respectively. The removal of DPPH free radical increased in OLE and all 5 fractions of OLE in a concentration dependent manner. In order to investigate the antioxidant effect of OLE in vitro, 80%(v/v) ethanol OLE, H₂O₂, or combined treatment of 80%(v/v) ethanol OLE and H₂O₂ were applied on mouse embryonic fibroblast (MEF) cells. Cells were damaged by oxidative stress decreased their viability followed by increasing concentration of H₂O₂, but co-treatment of OLE and H₂O₂ showed an increase in cell growth about 20% compare to the cells treated with H₂O₂. OLE suppresses cytotoxicity induced by H₂O₂ in dose dependent manner. OLE treatment on MEF cells was also examined by analyzing cell cycle and apoptotic rate using flow cytometry. Apoptotic and necrotic cell accumulation was decreased in addition of OLE to H₂O₂ compare to the oxidative damaged cells. Taken together, these results demonstrated that OLE suppresses cytotoxicity induced by H2O2 and protect cells against oxidative stress on MEF cells.
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목차
- Abstract
- Introduction
- Materials and Methods
- Results and Discussion
- References
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UCI(KEPA) : I410-ECN-0101-2013-573-000874794
