메뉴 건너뛰기
소속 기관 / 학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
고객센터 ENG
주제분류

논문 기본 정보

저자정보
(Chungbuk National University) (Chungbuk National University) (Biotoxtech) (Chungbuk National University)
저널정보
충북대학교 동물의학연구소 Journal of Biomedical Research Journal of Biomedical Research Vol.12 No.3
오류 신고하기

피인용 0

검색

    초록·키워드

    The effects The present study was designed to investigate the effect of Red ginseng extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week old animals were given four times for two weeks subcutaneous injections of DMH (30 mg/kg body weight) to induce ACF. The animals were divided into groups that fed diet containing red ginseng extract at three different doses (0.5, 1.0, 2.0%), respectively. Animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. Four-time treatment with DMH induced mean 265.8±48.3 ACF/colon composed of total 608.8±110.9 aberrant crypts AC/colon. The numbers of ACF and AC induced by DMH were decreased to 204.4±29.3 and 464.7±70.3 by treatment with 0.5% red ginseng extract. Moreover, the number of large ACF (≥4 AC/ACF) was suppressed from 39.9±10.6 ACF/colon in control to 28.5±5.3 ACF/colon in 0.5% red ginseng extract. These results suggested that red ginseng extract exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the development of ACF and AC in the F344 rats.

    최근 본 자료 전체보기

      UCI(KEPA) : I410-ECN-0101-2013-528-002902370