인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
The present study was performed to investigate the effect of resistance exercise on aged muscle protein synthesis. Young (12 wk, n=28) and aged (100 wk, n=26) male, Sprague-Dawley rats (n = 56) were randomly assigned to the time course of resistance exercise. Ladder climbing was performed with a 1 m wire ladder, at an 85° angle and the weight bearing was added to the tail (1RM 60~80%, total 25~30 climbs/h). Muscle samples were obtained before and recovery period of the exercise (pre, immediately after, recovery 1hr, and 3hr from the climbing). Protein expressions were analyzed for PKB/Akt, mammalian target of rapamycin (mTOR), p70S6 kinase (p70S6k), eukaryotic initiation factor (eIF) 4E-binding protein (BE-BP1) and AMPK phosphorylation. This type of resistance exercise generated a significant increase in mTOR phosphorylation immediately after exercise in aged rats (~71%, p=.02). In addition, 4EBP1 Phosphorylation was significantly decreased at the immediately (~42%, p=.05) after exercise and decreased up to an hour recovery. However, Phosphorylation of p70S6K was elevated above rest level throughout the 3hrs recovery(347%, p=.004). On the other hand, Phospho-AMPK (Thr172) tended to be greater than the young rats. These results suggest that the intensitive resistance exercise positively effect on muscle protein synthesis in aged skeletal muscle.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
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UCI(KEPA) : I410-ECN-0101-2014-692-000786088
