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논문 기본 정보

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(고려대학교) (메사추세츠 공과대학교) (메사추세츠 공과대학교) (고려대학교)
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대한기계학회 대한기계학회 춘추학술대회 대한기계학회 2013년도 바이오공학부문 춘계학술대회 논문집
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    초록·키워드

    One of the most advantageous feature of particulate drug delivery system is its engineerability and multi-functionality. Recently, advance of nanotechnology enables to fabricate diverse shape of particle. Additionally, by conjugating multiple functional molecule, multi-functional drug delivery system can be achieved. Especially, by designing geometry of particle, it is possible to control the particle adhesion to the vasculature wall effectively. In this study, the flow in the cell free layer is assumed to be linear shear flow and the trajectory of non-spherical particle is calculated. Non-spherical particle design strategy to enhance vascular interaction of is presented. In contrast to the spherical particle, which shows translational motion in the flow direction, non-spherical particle shows drift toward the wall in the cell free layer. Also, the different particle shape shows different margination speed. It is shown that discoidal particle with low aspect ratio gives more chance to interact with the vasculature wall. The construction of in vitro m ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2014-500-002566263