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(Wonkwang University) (Wonkwang University) (Wonkwang University) (Wonkwang University) (Wonkwang University) (Wonkwang University) (Huvet Co.) (Korea DNA Valley Co) (Wonkwang University)
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한국실험동물학회 한국실험동물학회 학술발표대회 논문집 2012년 한국실험동물학회 국제학술대회
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    초록·키워드

    The present study investigated the protective effects of melatonin (MT) against gentamicin (GM)-induced nephrotoxicity and oxidative stress in rats. In addition, we investigated the effects of MT on induction of apoptotic cell death and its potential mechanisms in renal tissues in response to GM treatment. The following four experimental groups were evaluated: (1) vehicle control, (2) MT (15 mg/kg/day), (3) GM (100 mg/kg/day), and (4) GM&MT. GM was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum blood urea nitrogen and creatinine levels and increased renal tubular cell apoptosis and the protein expression of Bcl2-associated X protein (Bax) and cleaved caspase-3. In addition, GM treatment caused an increase in levels of inducible nitric oxide syntha ... 전체 초록 보기

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