인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The biological studies related to the diameter of TiO₂ nanotube have mainly focused on the biocompatibility and functionality of cells. The purpose of this study was to evaluate the size effect of various TiO₂ nanotube diameters on inflammatory responses such as the generation of iNOS, NO and interleukin-1β(IL-1β), and tumor necrosis factor-α(TNF-α) in LPS-stimulated Raw 264.7 macrophages. The adhesion and proliferation of macrophages cultured on 100 nm Ti02 nanotube were significantly higher than those cultured on Ti(P (0.05). The results of nitric oxide(NO) generation from macrophage indicated that the value of 30 and 100 ㎚ TiO₂ nanotube had the tendency of reduction and increment, respectively, compared to Ti control group(P>0.05). The mRNA expression of iNOS, IL-1β and TNF-α resulted that the IL-1β (the degree of inflammation response) values of 30 ㎚ TiO₂ nanotube was significantly lower than those of Ti(P<0.05). In additions, IL-1β values of 100 ㎚ TiO₂ nanotube was significantly higher than those of Ti(P<0.05) Thus, it was concluded that TiO₂ nanotube did not have cytotoxicity effect on RAW 264.7 macrophage, but 100 ㎚ TiO₂ nanotube had the potential for accelerating inflammation response in Raw 264.7 macrophages. Further investigation is required to resolve detailed mechanisms relating to the morphology and nanostructure of TiO₂ nanotube and inflammation response.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
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최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2015-510-001110501