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Synergistic effect of quercetin and silver nanoparticles on HeLa cancer cells
논문 기본 정보
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 279 - 279 (1page)
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Synergistic effect of quercetin and silver nanoparticles on HeLa cancer cells
초록·키워드
Zygomycota is one of the less characterized phyla of marine microorganisms. An investigation of marine algae surface-associated fungal community led to the isolation of previously undescribed Mucor strain. All the characteristic features of the genus Mucor, sporangiophores, sporangium, sporangiospores and columellae, were apparent in Scan Electron Microscope (SEM) images of the isolated strain. The sequence of the internal transcribed spacer (ITS) rDNA and cellular fatty acid analysis revealed that the strain exhibits 97% of homology to the genus Mucor. Tyrosol, (2-(4-hydroxyphenyl)ethanol), was isolated as a major secondary metabolites form ethyl acetate extract of the culture broth and structure of the compound was established through spectroscopic data (1H NMR, 13C NMR and MS). Productivity of tyrosol was considerably higher than that of reported tyrosol producing microorganisms and optimum conditions, culture media, incubation period, temperature and pH, were identified for the production of tyrosol. In conclusion, the finding clearly demonstrates that the novel strain have potential to be developed as a natural source for producing tyrosol for industrial purposes.
Biosynthesis of nanoparticles from microbes has wide biomedical applications, research interest in nanotechnology and microbial biotechnology. Silver nanoparticles synthesized from using a novel Nocardiopsis sp. MBRC-1 strain. Quercetin is a polyphenolic flavanoid compound possesses antioxidant and cytotoxic activity. This study investigated the effect of silver nanoparticles (AgNPs) and quercetin on HeLa cancer cell viability and apoptosis. The prepared silver nanoparticles and quercetin have strong cytotoxic effects and also combination of both exhibited signific ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2015-400-001257519
