인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
In the present study, the effects of resistance exercise on spatial learning memory ability, the synapses and the synaptic-plasticity neurotrophic factor in hippocampus in aged-rats with diabetes was investigated. The experimental animals were divided into three groups(n= 15 in each group): the normal control group(NCG), the diabetes + aging control group(DACG), the diabetes, aging and exercise group(DAEG). Animals in the exercise group were submitted to daily exercise on the tower climbing during 8weeks. The spatial learning and memory capability was evaluated by Morris water maze in a separate set of rats. Western blotting analysis for the expression of BDNF, PSD-95 and Synapsin 1 was performed. Electron microscopy methods were used to evaluate synaptic plasticity. In the present study, quantitiative electron microscopy was used to investigate morphological changes in the hippocampus. Measurements taken from analysis of the electron micrograph sets were used to calculate the spine synapses in hippocampus. Here in this study, it have shown that both synaptic-plasticity neurotrophic factor expression and spine synapses were suppressed in the DAC group, whereas tower climbing exercise alleviated the aging-induced suppression of both synaptic-plasticity neurotrophic factor expression and spine synapses in the hippocampus of rats. The results of the present study indicate that tower climbing exercise may facilitate recovery from the CNS complications associated with aging and diabetes by inducing enhanced the morphological development of synapses in the hippocampus via the augmentation of synaptic-plasticity neurotrophic factor expression in the hippocampus.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2015-690-002913416
